Gadolinium-based contrast agents in pediatric magnetic resonance imaging

Eric M. Gale, Peter Caravan, Anil G. Rao, Robert McDonald, Matthew Winfeld, Robert J. Fleck, Michael S. Gee

Research output: Contribution to journalReview article

20 Scopus citations

Abstract

Gadolinium-based contrast agents can increase the accuracy and expediency of an MRI examination. However the benefits of a contrast-enhanced scan must be carefully weighed against the well-documented risks associated with administration of exogenous contrast media. The purpose of this review is to discuss commercially available gadolinium-based contrast agents (GBCAs) in the context of pediatric radiology. We discuss the chemistry, regulatory status, safety and clinical applications, with particular emphasis on imaging of the blood vessels, heart, hepatobiliary tree and central nervous system. We also discuss non-GBCA MRI contrast agents that are less frequently used or not commercially available.

Original languageEnglish (US)
Pages (from-to)507-521
Number of pages15
JournalPediatric Radiology
Volume47
Issue number5
DOIs
StatePublished - May 1 2017

Keywords

  • Children
  • Contrast agent
  • Gadolinium-based contrast agent
  • Magnetic resonance imaging
  • Safety

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Gale, E. M., Caravan, P., Rao, A. G., McDonald, R., Winfeld, M., Fleck, R. J., & Gee, M. S. (2017). Gadolinium-based contrast agents in pediatric magnetic resonance imaging. Pediatric Radiology, 47(5), 507-521. https://doi.org/10.1007/s00247-017-3806-0