GAD65 antibody-associated autoimmune epilepsy with unique independent bitemporal-onset ictal asystole

Caitlin E. D'Souza, Anteneh Feyissa

Research output: Contribution to journalComment/debate

2 Scopus citations


Antibodies against the 65-kDa isoform of the intracellular enzyme, glutamate decarboxylase (GAD65), have been found in patients with limbic encephalitis and drug-resistant autoimmune epilepsy. We report a 22-year-old female who presented with new-onset seizures and neuropsychiatric symptoms. Video-EEG captured unique, independent bitemporal-onset focal seizures with impaired awareness and ictal asystole. An autoimmune epilepsy panel revealed elevated GAD65 antibodies in the serum (225 nmol/l) and CSF (2.78 nmol/l), while [18F]-fluoro-deoxy-glucose positron emission tomography showed bitemporal hypometabolism (left > right). The patient was diagnosed with GAD65 antibody-associated autoimmune epilepsy. Our observation adds to the spectrum of neurocardiac syndromes associated with autoimmune epilepsy.

Original languageEnglish (US)
Pages (from-to)204-208
Number of pages5
JournalEpileptic Disorders
Issue number3
StatePublished - Jun 1 2018



  • asystole
  • autoimmune epilepsy
  • focal epilepsy
  • GAD65
  • limbic encephalitis
  • neurocardiac syndromes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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