Abstract
Antibodies against the 65-kDa isoform of the intracellular enzyme, glutamate decarboxylase (GAD65), have been found in patients with limbic encephalitis and drug-resistant autoimmune epilepsy. We report a 22-year-old female who presented with new-onset seizures and neuropsychiatric symptoms. Video-EEG captured unique, independent bitemporal-onset focal seizures with impaired awareness and ictal asystole. An autoimmune epilepsy panel revealed elevated GAD65 antibodies in the serum (225 nmol/l) and CSF (2.78 nmol/l), while [18F]-fluoro-deoxy-glucose positron emission tomography showed bitemporal hypometabolism (left > right). The patient was diagnosed with GAD65 antibody-associated autoimmune epilepsy. Our observation adds to the spectrum of neurocardiac syndromes associated with autoimmune epilepsy.
Original language | English (US) |
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Pages (from-to) | 204-208 |
Number of pages | 5 |
Journal | Epileptic Disorders |
Volume | 20 |
Issue number | 3 |
DOIs |
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State | Published - Jun 2018 |
Keywords
- GAD65
- asystole
- autoimmune epilepsy
- focal epilepsy
- limbic encephalitis
- neurocardiac syndromes
ASJC Scopus subject areas
- Neurology
- Clinical Neurology