G protein-coupled receptor structures, molecular associations, and modes of regulation

Laurence J. Miller

doi:10.1196/annals.1418.000

G protein-coupled receptor structures, molecular associations, and modes of regulation

Laurence J. Miller

Gastroenterology and Hepatology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

4 Scopus citations

Abstract

G protein-coupled receptors are present on every excitable and regulatable cell in the body and represent important potential sites for drug action. This group of molecules already represents the most common target for currently approved drugs. With recent advances in our understanding of detailed molecular structure, mechanisms of activation, unique molecular associations, and cellular and biochemical mechanisms of regulation of these receptors, development and refinement of receptor-active drugs should benefit substantially. In this report, key past accomplishments and possible future directions for this field of research are reviewed.

Original language	English (US)
Title of host publication	Neural Signaling Opportunities for Novel Diagnostic Approaches and Therapies
Publisher	Blackwell Publishing Inc.
Pages	1-5
Number of pages	5
ISBN (Print)	9781573317047
DOIs	https://doi.org/10.1196/annals.1418.000
State	Published - Nov 2008

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1144
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Allosteric modulation
G protein-coupled receptors
Ligand binding
Receptor oligomerization
Receptor structure
Receptor-associated proteins

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

Access to Document

10.1196/annals.1418.000

Cite this

G protein-coupled receptor structures, molecular associations, and modes of regulation. / Miller, Laurence J.
Neural Signaling Opportunities for Novel Diagnostic Approaches and Therapies. Blackwell Publishing Inc., 2008. p. 1-5 (Annals of the New York Academy of Sciences; Vol. 1144).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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G protein-coupled receptor structures, molecular associations, and modes of regulation

Abstract

Publication series

Keywords

ASJC Scopus subject areas

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