G protein-coupled receptor structures, molecular associations, and modes of regulation

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


G protein-coupled receptors are present on every excitable and regulatable cell in the body and represent important potential sites for drug action. This group of molecules already represents the most common target for currently approved drugs. With recent advances in our understanding of detailed molecular structure, mechanisms of activation, unique molecular associations, and cellular and biochemical mechanisms of regulation of these receptors, development and refinement of receptor-active drugs should benefit substantially. In this report, key past accomplishments and possible future directions for this field of research are reviewed.

Original languageEnglish (US)
Title of host publicationNeural Signaling Opportunities for Novel Diagnostic Approaches and Therapies
PublisherBlackwell Publishing Inc.
Number of pages5
ISBN (Print)9781573317047
StatePublished - Nov 2008

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Allosteric modulation
  • G protein-coupled receptors
  • Ligand binding
  • Receptor oligomerization
  • Receptor structure
  • Receptor-associated proteins

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


Dive into the research topics of 'G protein-coupled receptor structures, molecular associations, and modes of regulation'. Together they form a unique fingerprint.

Cite this