G protein-coupled receptor structures, molecular associations, and modes of regulation

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

G protein-coupled receptors are present on every excitable and regulatable cell in the body and represent important potential sites for drug action. This group of molecules already represents the most common target for currently approved drugs. With recent advances in our understanding of detailed molecular structure, mechanisms of activation, unique molecular associations, and cellular and biochemical mechanisms of regulation of these receptors, development and refinement of receptor-active drugs should benefit substantially. In this report, key past accomplishments and possible future directions for this field of research are reviewed.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages1-5
Number of pages5
Volume1144
DOIs
StatePublished - Nov 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1144
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

G-Protein-Coupled Receptors
Molecular Structure
Molecular structure
Drug Receptors
Pharmaceutical Preparations
Chemical activation
Research
Molecules
Direction compound
Cell Body

Keywords

  • Allosteric modulation
  • G protein-coupled receptors
  • Ligand binding
  • Receptor oligomerization
  • Receptor structure
  • Receptor-associated proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Miller, L. J. (2008). G protein-coupled receptor structures, molecular associations, and modes of regulation. In Annals of the New York Academy of Sciences (Vol. 1144, pp. 1-5). (Annals of the New York Academy of Sciences; Vol. 1144). https://doi.org/10.1196/annals.1418.000

G protein-coupled receptor structures, molecular associations, and modes of regulation. / Miller, Laurence J.

Annals of the New York Academy of Sciences. Vol. 1144 2008. p. 1-5 (Annals of the New York Academy of Sciences; Vol. 1144).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Miller, LJ 2008, G protein-coupled receptor structures, molecular associations, and modes of regulation. in Annals of the New York Academy of Sciences. vol. 1144, Annals of the New York Academy of Sciences, vol. 1144, pp. 1-5. https://doi.org/10.1196/annals.1418.000
Miller LJ. G protein-coupled receptor structures, molecular associations, and modes of regulation. In Annals of the New York Academy of Sciences. Vol. 1144. 2008. p. 1-5. (Annals of the New York Academy of Sciences). https://doi.org/10.1196/annals.1418.000
Miller, Laurence J. / G protein-coupled receptor structures, molecular associations, and modes of regulation. Annals of the New York Academy of Sciences. Vol. 1144 2008. pp. 1-5 (Annals of the New York Academy of Sciences).
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