Future of endoscopy and IBD

Michael Wallace

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Advanced endoscopic imaging has the potential to bridge the gap between endoscopy and the precision and predictive power of pathology and molecular medicine. Practical advances in endoscopy include the real ability to move beyond low-yield random biopsy to image-guided targeted biopsy. Advanced imaging now allows endoscopic removal of discrete adenomatous lesions, reserving surgery for DALM lesions with unclear borders. Clinical trials and practice is increasingly using mucosal healing to determine therapeutic response. This will extend to advanced imaging to assess mucosal healing at an endoscopic, histologic, and molecular level. Molecular imaging now allows direction endoscopic assessment of drug binding, which will allow selection of specific monoclonal antibody and other targeted therapy. By directly assessing drug binding in vivo, these technologies will speed drug development and provide more precise short-term outcomes.

Original languageEnglish (US)
Title of host publicationEndoscopy in Inflammatory Bowel Disease
PublisherSpringer International Publishing
Pages325-328
Number of pages4
ISBN (Print)9783319110776, 9783319110769
DOIs
StatePublished - Jan 1 2015

Keywords

  • Autofluorescence imaging
  • Confocal endomicroscopy
  • Dysplasia
  • Molecular imaging
  • Targeted biopsies

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Future of endoscopy and IBD'. Together they form a unique fingerprint.

Cite this