Future mechanisms of reversing kidney injury

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The search for effective strategies to protect the stenotic kidney or to facilitate recovery of kidney function has been the holy grail of the field of renal vascular disease and renovascular hypertension. Over the past few years, a number of novel interventions have been applied in an attempt to blunt and reverse functional and structural kidney remodeling distal to renal artery stenosis. Many of these interventions were designed to target specific deleterious cascades that are activated in the post stenotic kidney, such as mitochondrial injury, inadequate intrinsic regeneration mechanisms, downregulation of angiogenic pathways, and processes that promote inflammation or fibrosis. Emerging strategies show promise to revitalize the renal parenchyma regardless of restoration of proximal renal arterial patency. Such developments could improve our success in treating this important cause of kidney injury and cardiovascular morbidity and mortality.

Original languageEnglish (US)
Title of host publicationRenal Vascular Disease
PublisherSpringer-Verlag London Ltd
Pages345-351
Number of pages7
Volume9781447128106
ISBN (Print)9781447128106, 1447128095, 9781447128090
DOIs
StatePublished - Dec 1 2014

Fingerprint

Kidney
Wounds and Injuries
Renovascular Hypertension
Renal Artery Obstruction
Recovery of Function
Vascular Diseases
Regeneration
Fibrosis
Down-Regulation
Inflammation
Morbidity
Mortality

Keywords

  • Fibrosis
  • Inflammation
  • Regenerative medicine
  • Renal artery stenosis
  • Revascularization

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lerman, L. O. (2014). Future mechanisms of reversing kidney injury. In Renal Vascular Disease (Vol. 9781447128106, pp. 345-351). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-2810-6_22

Future mechanisms of reversing kidney injury. / Lerman, Lilach O.

Renal Vascular Disease. Vol. 9781447128106 Springer-Verlag London Ltd, 2014. p. 345-351.

Research output: Chapter in Book/Report/Conference proceedingChapter

Lerman, LO 2014, Future mechanisms of reversing kidney injury. in Renal Vascular Disease. vol. 9781447128106, Springer-Verlag London Ltd, pp. 345-351. https://doi.org/10.1007/978-1-4471-2810-6_22
Lerman LO. Future mechanisms of reversing kidney injury. In Renal Vascular Disease. Vol. 9781447128106. Springer-Verlag London Ltd. 2014. p. 345-351 https://doi.org/10.1007/978-1-4471-2810-6_22
Lerman, Lilach O. / Future mechanisms of reversing kidney injury. Renal Vascular Disease. Vol. 9781447128106 Springer-Verlag London Ltd, 2014. pp. 345-351
@inbook{b6a7ce180c65492ba612d1db838c14c2,
title = "Future mechanisms of reversing kidney injury",
abstract = "The search for effective strategies to protect the stenotic kidney or to facilitate recovery of kidney function has been the holy grail of the field of renal vascular disease and renovascular hypertension. Over the past few years, a number of novel interventions have been applied in an attempt to blunt and reverse functional and structural kidney remodeling distal to renal artery stenosis. Many of these interventions were designed to target specific deleterious cascades that are activated in the post stenotic kidney, such as mitochondrial injury, inadequate intrinsic regeneration mechanisms, downregulation of angiogenic pathways, and processes that promote inflammation or fibrosis. Emerging strategies show promise to revitalize the renal parenchyma regardless of restoration of proximal renal arterial patency. Such developments could improve our success in treating this important cause of kidney injury and cardiovascular morbidity and mortality.",
keywords = "Fibrosis, Inflammation, Regenerative medicine, Renal artery stenosis, Revascularization",
author = "Lerman, {Lilach O}",
year = "2014",
month = "12",
day = "1",
doi = "10.1007/978-1-4471-2810-6_22",
language = "English (US)",
isbn = "9781447128106",
volume = "9781447128106",
pages = "345--351",
booktitle = "Renal Vascular Disease",
publisher = "Springer-Verlag London Ltd",

}

TY - CHAP

T1 - Future mechanisms of reversing kidney injury

AU - Lerman, Lilach O

PY - 2014/12/1

Y1 - 2014/12/1

N2 - The search for effective strategies to protect the stenotic kidney or to facilitate recovery of kidney function has been the holy grail of the field of renal vascular disease and renovascular hypertension. Over the past few years, a number of novel interventions have been applied in an attempt to blunt and reverse functional and structural kidney remodeling distal to renal artery stenosis. Many of these interventions were designed to target specific deleterious cascades that are activated in the post stenotic kidney, such as mitochondrial injury, inadequate intrinsic regeneration mechanisms, downregulation of angiogenic pathways, and processes that promote inflammation or fibrosis. Emerging strategies show promise to revitalize the renal parenchyma regardless of restoration of proximal renal arterial patency. Such developments could improve our success in treating this important cause of kidney injury and cardiovascular morbidity and mortality.

AB - The search for effective strategies to protect the stenotic kidney or to facilitate recovery of kidney function has been the holy grail of the field of renal vascular disease and renovascular hypertension. Over the past few years, a number of novel interventions have been applied in an attempt to blunt and reverse functional and structural kidney remodeling distal to renal artery stenosis. Many of these interventions were designed to target specific deleterious cascades that are activated in the post stenotic kidney, such as mitochondrial injury, inadequate intrinsic regeneration mechanisms, downregulation of angiogenic pathways, and processes that promote inflammation or fibrosis. Emerging strategies show promise to revitalize the renal parenchyma regardless of restoration of proximal renal arterial patency. Such developments could improve our success in treating this important cause of kidney injury and cardiovascular morbidity and mortality.

KW - Fibrosis

KW - Inflammation

KW - Regenerative medicine

KW - Renal artery stenosis

KW - Revascularization

UR - http://www.scopus.com/inward/record.url?scp=84949176676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949176676&partnerID=8YFLogxK

U2 - 10.1007/978-1-4471-2810-6_22

DO - 10.1007/978-1-4471-2810-6_22

M3 - Chapter

SN - 9781447128106

SN - 1447128095

SN - 9781447128090

VL - 9781447128106

SP - 345

EP - 351

BT - Renal Vascular Disease

PB - Springer-Verlag London Ltd

ER -