Future mechanisms of reversing kidney injury

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The search for effective strategies to protect the stenotic kidney or to facilitate recovery of kidney function has been the holy grail of the field of renal vascular disease and renovascular hypertension. Over the past few years, a number of novel interventions have been applied in an attempt to blunt and reverse functional and structural kidney remodeling distal to renal artery stenosis. Many of these interventions were designed to target specific deleterious cascades that are activated in the post stenotic kidney, such as mitochondrial injury, inadequate intrinsic regeneration mechanisms, downregulation of angiogenic pathways, and processes that promote inflammation or fibrosis. Emerging strategies show promise to revitalize the renal parenchyma regardless of restoration of proximal renal arterial patency. Such developments could improve our success in treating this important cause of kidney injury and cardiovascular morbidity and mortality.

Original languageEnglish (US)
Title of host publicationRenal Vascular Disease
PublisherSpringer-Verlag London Ltd
Pages345-351
Number of pages7
Volume9781447128106
ISBN (Print)9781447128106, 1447128095, 9781447128090
DOIs
StatePublished - Dec 1 2014

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Keywords

  • Fibrosis
  • Inflammation
  • Regenerative medicine
  • Renal artery stenosis
  • Revascularization

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Lerman, L. O. (2014). Future mechanisms of reversing kidney injury. In Renal Vascular Disease (Vol. 9781447128106, pp. 345-351). Springer-Verlag London Ltd. https://doi.org/10.1007/978-1-4471-2810-6_22