Abstract
The search for effective strategies to protect the stenotic kidney or to facilitate recovery of kidney function has been the holy grail of the field of renal vascular disease and renovascular hypertension. Over the past few years, a number of novel interventions have been applied in an attempt to blunt and reverse functional and structural kidney remodeling distal to renal artery stenosis. Many of these interventions were designed to target specific deleterious cascades that are activated in the post stenotic kidney, such as mitochondrial injury, inadequate intrinsic regeneration mechanisms, downregulation of angiogenic pathways, and processes that promote inflammation or fibrosis. Emerging strategies show promise to revitalize the renal parenchyma regardless of restoration of proximal renal arterial patency. Such developments could improve our success in treating this important cause of kidney injury and cardiovascular morbidity and mortality.
| Original language | English (US) |
|---|---|
| Title of host publication | Renal Vascular Disease |
| Publisher | Springer-Verlag London Ltd |
| Pages | 345-351 |
| Number of pages | 7 |
| Volume | 9781447128106 |
| ISBN (Print) | 9781447128106, 1447128095, 9781447128090 |
| DOIs | |
| State | Published - Dec 1 2014 |
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Keywords
- Fibrosis
- Inflammation
- Regenerative medicine
- Renal artery stenosis
- Revascularization
ASJC Scopus subject areas
- Medicine(all)
Cite this
Future mechanisms of reversing kidney injury. / Lerman, Lilach O.
Renal Vascular Disease. Vol. 9781447128106 Springer-Verlag London Ltd, 2014. p. 345-351.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Future mechanisms of reversing kidney injury
AU - Lerman, Lilach O
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The search for effective strategies to protect the stenotic kidney or to facilitate recovery of kidney function has been the holy grail of the field of renal vascular disease and renovascular hypertension. Over the past few years, a number of novel interventions have been applied in an attempt to blunt and reverse functional and structural kidney remodeling distal to renal artery stenosis. Many of these interventions were designed to target specific deleterious cascades that are activated in the post stenotic kidney, such as mitochondrial injury, inadequate intrinsic regeneration mechanisms, downregulation of angiogenic pathways, and processes that promote inflammation or fibrosis. Emerging strategies show promise to revitalize the renal parenchyma regardless of restoration of proximal renal arterial patency. Such developments could improve our success in treating this important cause of kidney injury and cardiovascular morbidity and mortality.
AB - The search for effective strategies to protect the stenotic kidney or to facilitate recovery of kidney function has been the holy grail of the field of renal vascular disease and renovascular hypertension. Over the past few years, a number of novel interventions have been applied in an attempt to blunt and reverse functional and structural kidney remodeling distal to renal artery stenosis. Many of these interventions were designed to target specific deleterious cascades that are activated in the post stenotic kidney, such as mitochondrial injury, inadequate intrinsic regeneration mechanisms, downregulation of angiogenic pathways, and processes that promote inflammation or fibrosis. Emerging strategies show promise to revitalize the renal parenchyma regardless of restoration of proximal renal arterial patency. Such developments could improve our success in treating this important cause of kidney injury and cardiovascular morbidity and mortality.
KW - Fibrosis
KW - Inflammation
KW - Regenerative medicine
KW - Renal artery stenosis
KW - Revascularization
UR - http://www.scopus.com/inward/record.url?scp=84949176676&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949176676&partnerID=8YFLogxK
U2 - 10.1007/978-1-4471-2810-6_22
DO - 10.1007/978-1-4471-2810-6_22
M3 - Chapter
SN - 9781447128106
SN - 1447128095
SN - 9781447128090
VL - 9781447128106
SP - 345
EP - 351
BT - Renal Vascular Disease
PB - Springer-Verlag London Ltd
ER -