Further evidence that the tachycardiac response to 5-hydroxytryptamine in rats is not mediated via typical 5-HT2 receptors

Milovan K. Krstic, Zvonimir S. Katušić

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

1. In pithed rats, the receptor type of cardiac tissue mediating the tachycardiac response to 5-hydroxytryptamine (5-HT) was analysed. 2. Ketanserin, mesulergine and methiothepin, administered in doses which antagonized the pressor response to 5-HT, slightly reduced, considerably reduced and antagonized, respectively, its tachycardiac response. 3. 8-OH DPAT and RU 24969 produced no significant tachycardia, while DOI neither mimicked nor blocked the 5-HT-induced tachycardia. 4. The tachycardia was not affected by MDL 72222, metoclopramide and cocaine. 5. The hypothesis is proposed that in rats the tachycardiac response to 5-HT is mediated via 5-HT receptors belonging to an yet unclassified subtype of 5-HT1 or 5-HT2 receptors.

Original languageEnglish (US)
Pages (from-to)917-921
Number of pages5
JournalGeneral Pharmacology
Volume25
Issue number5
DOIs
StatePublished - Sep 1994

Keywords

  • 5-Hydroxytryptamine
  • 8-OH DPAT
  • MDL 72222
  • RU 24969
  • ketanserin
  • mesulergine
  • methiothepin
  • rat heart

ASJC Scopus subject areas

  • Pharmacology

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