Further degradation product of hyperforin from Hypericum perforatum (St. John's Wort)

V. Vajs, S. Vugdelija, S. Trifunović, I. Karadžić, N. Juranić, Slobodan I Macura, S. Milosavljević

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Repeated examination of the aerial parts of Hypericum perforatum yielded a new degradation product of hyperforin (1) namely deoxyfurohyperforin A (2), together with the previously identified furohyperforin (3), furoadhyperforin (4), furohyperforin A (5a and 5b), pyrano[7,28-b]hyperforin (6) and 3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3- pentenyl)-cyclohexanone (7). The antimicrobial activity of the compounds 3, 5a and 5b, 6 and 7 was tested against Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli.

Original languageEnglish (US)
Pages (from-to)439-444
Number of pages6
JournalFitoterapia
Volume74
Issue number5
DOIs
StatePublished - Jul 2003

Fingerprint

Hypericum
Bacillus subtilis
Candida albicans
Staphylococcus aureus
Escherichia coli
hyperforin
cyclohexanone
deoxyfurohyperforin A

Keywords

  • Antimicrobial activity
  • Deoxyfurohyperforin A
  • Hypericum perforatum

ASJC Scopus subject areas

  • Pharmacology

Cite this

Vajs, V., Vugdelija, S., Trifunović, S., Karadžić, I., Juranić, N., Macura, S. I., & Milosavljević, S. (2003). Further degradation product of hyperforin from Hypericum perforatum (St. John's Wort). Fitoterapia, 74(5), 439-444. https://doi.org/10.1016/S0367-326X(03)00114-X

Further degradation product of hyperforin from Hypericum perforatum (St. John's Wort). / Vajs, V.; Vugdelija, S.; Trifunović, S.; Karadžić, I.; Juranić, N.; Macura, Slobodan I; Milosavljević, S.

In: Fitoterapia, Vol. 74, No. 5, 07.2003, p. 439-444.

Research output: Contribution to journalArticle

Vajs, V, Vugdelija, S, Trifunović, S, Karadžić, I, Juranić, N, Macura, SI & Milosavljević, S 2003, 'Further degradation product of hyperforin from Hypericum perforatum (St. John's Wort)', Fitoterapia, vol. 74, no. 5, pp. 439-444. https://doi.org/10.1016/S0367-326X(03)00114-X
Vajs, V. ; Vugdelija, S. ; Trifunović, S. ; Karadžić, I. ; Juranić, N. ; Macura, Slobodan I ; Milosavljević, S. / Further degradation product of hyperforin from Hypericum perforatum (St. John's Wort). In: Fitoterapia. 2003 ; Vol. 74, No. 5. pp. 439-444.
@article{e232f1187e464f32af0ed3c35b9a144a,
title = "Further degradation product of hyperforin from Hypericum perforatum (St. John's Wort)",
abstract = "Repeated examination of the aerial parts of Hypericum perforatum yielded a new degradation product of hyperforin (1) namely deoxyfurohyperforin A (2), together with the previously identified furohyperforin (3), furoadhyperforin (4), furohyperforin A (5a and 5b), pyrano[7,28-b]hyperforin (6) and 3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3- pentenyl)-cyclohexanone (7). The antimicrobial activity of the compounds 3, 5a and 5b, 6 and 7 was tested against Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli.",
keywords = "Antimicrobial activity, Deoxyfurohyperforin A, Hypericum perforatum",
author = "V. Vajs and S. Vugdelija and S. Trifunović and I. Karadžić and N. Juranić and Macura, {Slobodan I} and S. Milosavljević",
year = "2003",
month = "7",
doi = "10.1016/S0367-326X(03)00114-X",
language = "English (US)",
volume = "74",
pages = "439--444",
journal = "Fitoterapia",
issn = "0367-326X",
publisher = "Elsevier",
number = "5",

}

TY - JOUR

T1 - Further degradation product of hyperforin from Hypericum perforatum (St. John's Wort)

AU - Vajs, V.

AU - Vugdelija, S.

AU - Trifunović, S.

AU - Karadžić, I.

AU - Juranić, N.

AU - Macura, Slobodan I

AU - Milosavljević, S.

PY - 2003/7

Y1 - 2003/7

N2 - Repeated examination of the aerial parts of Hypericum perforatum yielded a new degradation product of hyperforin (1) namely deoxyfurohyperforin A (2), together with the previously identified furohyperforin (3), furoadhyperforin (4), furohyperforin A (5a and 5b), pyrano[7,28-b]hyperforin (6) and 3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3- pentenyl)-cyclohexanone (7). The antimicrobial activity of the compounds 3, 5a and 5b, 6 and 7 was tested against Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli.

AB - Repeated examination of the aerial parts of Hypericum perforatum yielded a new degradation product of hyperforin (1) namely deoxyfurohyperforin A (2), together with the previously identified furohyperforin (3), furoadhyperforin (4), furohyperforin A (5a and 5b), pyrano[7,28-b]hyperforin (6) and 3-methyl-4,6-di(3-methyl-2-butenyl)-2-(2-methyl-1-oxopropyl)-3-(4-methyl-3- pentenyl)-cyclohexanone (7). The antimicrobial activity of the compounds 3, 5a and 5b, 6 and 7 was tested against Staphylococcus aureus, Candida albicans, Bacillus subtilis and Escherichia coli.

KW - Antimicrobial activity

KW - Deoxyfurohyperforin A

KW - Hypericum perforatum

UR - http://www.scopus.com/inward/record.url?scp=0038691833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038691833&partnerID=8YFLogxK

U2 - 10.1016/S0367-326X(03)00114-X

DO - 10.1016/S0367-326X(03)00114-X

M3 - Article

C2 - 12837358

AN - SCOPUS:0038691833

VL - 74

SP - 439

EP - 444

JO - Fitoterapia

JF - Fitoterapia

SN - 0367-326X

IS - 5

ER -