Fungal infections in liver transplantation: Prophylaxis, surveillance, and treatment

Raymund R Razonable, Carlos V. Paya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Fungal infections are significant causes of morbidity and mortality after liver transplantation. Most of the fungal infections are caused by Candida albicans and less frequently by nonalbicans Candida species, Aspergillus species, and Cryptococcus neoformans. The pathogenesis, time of onset, and frequency of invasive fungal infections is unique for the different fungi and is influenced by defined host factors and level of immunosuppression. The improvements in surgical techniques, the dynamic practice of pharmacologic immunosuppression, the increasing awareness of predisposing risk factors, and the use of a variety of preventive strategies (including antifungal, antibacterial, and antiviral prophylaxis) have modified the epidemiology of fungal infection in patients undergoing liver transplantation. This article reviews the changing spectrum of postliver transplantation mycoses and discusses the current strategies in its surveillance, prevention, and treatment. Additionally, novel diagnostic methods and antifungal agents that may impact the treatment of fungal infection in recipients undergoing liver transplantation are discussed.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalCurrent Opinion in Organ Transplantation
Volume7
Issue number2
DOIs
StatePublished - 2002

Fingerprint

Mycoses
Liver Transplantation
Immunosuppression
Therapeutics
Cryptococcus neoformans
Antifungal Agents
Aspergillus
Candida albicans
Candida
Causality
Antiviral Agents
Epidemiology
Fungi
Transplantation
Morbidity
Mortality

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Fungal infections in liver transplantation : Prophylaxis, surveillance, and treatment. / Razonable, Raymund R; Paya, Carlos V.

In: Current Opinion in Organ Transplantation, Vol. 7, No. 2, 2002, p. 137-143.

Research output: Contribution to journalArticle

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