Fungal Infections After Lung Transplantation

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Infection remains a significant source of morbidity and mortality after lung transplant, including fungal infection. Various antifungal prophylaxis agents are administered for a variable duration after transplant with the goal of preventing invasive fungal infections. Alternatively, some programs target the use of antifungal agents only in those colonized with Aspergillus species. Despite prophylaxis or pre-emptive therapy, a significant number of invasive fungal infections occur after lung transplant. Risk factors for fungal infections include single lung transplant, pretransplant Aspergillus colonization, environmental risks, structural lung disease such as cystic fibrosis, augmented immunosuppression, sinus disease, and use of indwelling airway stents.

Original languageEnglish (US)
JournalClinics in Chest Medicine
DOIs
StateAccepted/In press - 2017

Fingerprint

Lung Transplantation
Mycoses
Transplants
Antifungal Agents
Aspergillus
Lung
Cystic Fibrosis
Immunosuppression
Lung Diseases
Stents
Morbidity
Mortality
Infection
Invasive Fungal Infections
Therapeutics

Keywords

  • Fungal infection
  • Fungal prophylaxis
  • Lung transplantation
  • Solid organ transplantation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

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title = "Fungal Infections After Lung Transplantation",
abstract = "Infection remains a significant source of morbidity and mortality after lung transplant, including fungal infection. Various antifungal prophylaxis agents are administered for a variable duration after transplant with the goal of preventing invasive fungal infections. Alternatively, some programs target the use of antifungal agents only in those colonized with Aspergillus species. Despite prophylaxis or pre-emptive therapy, a significant number of invasive fungal infections occur after lung transplant. Risk factors for fungal infections include single lung transplant, pretransplant Aspergillus colonization, environmental risks, structural lung disease such as cystic fibrosis, augmented immunosuppression, sinus disease, and use of indwelling airway stents.",
keywords = "Fungal infection, Fungal prophylaxis, Lung transplantation, Solid organ transplantation",
author = "Cassie Kennedy and Razonable, {Raymund R}",
year = "2017",
doi = "10.1016/j.ccm.2017.04.011",
language = "English (US)",
journal = "Clinics in Chest Medicine",
issn = "0272-5231",
publisher = "W.B. Saunders Ltd",

}

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AU - Kennedy, Cassie

AU - Razonable, Raymund R

PY - 2017

Y1 - 2017

N2 - Infection remains a significant source of morbidity and mortality after lung transplant, including fungal infection. Various antifungal prophylaxis agents are administered for a variable duration after transplant with the goal of preventing invasive fungal infections. Alternatively, some programs target the use of antifungal agents only in those colonized with Aspergillus species. Despite prophylaxis or pre-emptive therapy, a significant number of invasive fungal infections occur after lung transplant. Risk factors for fungal infections include single lung transplant, pretransplant Aspergillus colonization, environmental risks, structural lung disease such as cystic fibrosis, augmented immunosuppression, sinus disease, and use of indwelling airway stents.

AB - Infection remains a significant source of morbidity and mortality after lung transplant, including fungal infection. Various antifungal prophylaxis agents are administered for a variable duration after transplant with the goal of preventing invasive fungal infections. Alternatively, some programs target the use of antifungal agents only in those colonized with Aspergillus species. Despite prophylaxis or pre-emptive therapy, a significant number of invasive fungal infections occur after lung transplant. Risk factors for fungal infections include single lung transplant, pretransplant Aspergillus colonization, environmental risks, structural lung disease such as cystic fibrosis, augmented immunosuppression, sinus disease, and use of indwelling airway stents.

KW - Fungal infection

KW - Fungal prophylaxis

KW - Lung transplantation

KW - Solid organ transplantation

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