TY - JOUR
T1 - Fungal Infections After Lung Transplantation
AU - Kennedy, Cassie C.
AU - Razonable, Raymund R.
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/9
Y1 - 2017/9
N2 - Infection remains a significant source of morbidity and mortality after lung transplant, including fungal infection. Various antifungal prophylactic agents are administered for a variable duration after transplant with the goal of preventing invasive fungal infections. Alternatively, some programs target the use of antifungal agents only in those colonized with Aspergillus spp. Despite prophylaxis or preemptive therapy, a significant number of invasive fungal infections occur after lung transplant. Risk factors for fungal infections include single lung transplant, pretransplant Aspergillus colonization, environmental risks, structural lung disease such as cystic fibrosis, augmented immunosuppression, sinus disease, and use of indwelling airway stents.
AB - Infection remains a significant source of morbidity and mortality after lung transplant, including fungal infection. Various antifungal prophylactic agents are administered for a variable duration after transplant with the goal of preventing invasive fungal infections. Alternatively, some programs target the use of antifungal agents only in those colonized with Aspergillus spp. Despite prophylaxis or preemptive therapy, a significant number of invasive fungal infections occur after lung transplant. Risk factors for fungal infections include single lung transplant, pretransplant Aspergillus colonization, environmental risks, structural lung disease such as cystic fibrosis, augmented immunosuppression, sinus disease, and use of indwelling airway stents.
KW - Fungal infection
KW - Fungal prophylaxis
KW - Lung transplantation
KW - Solid organ transplantation
UR - http://www.scopus.com/inward/record.url?scp=85019866190&partnerID=8YFLogxK
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U2 - 10.1016/j.ccm.2017.04.011
DO - 10.1016/j.ccm.2017.04.011
M3 - Review article
C2 - 28797492
AN - SCOPUS:85019866190
SN - 0272-5231
VL - 38
SP - 511
EP - 520
JO - Clinics in Chest Medicine
JF - Clinics in Chest Medicine
IS - 3
ER -