Fundus autofluorescence in choroidal metastatic lesions a pilot study

Lucienne C. Collet, Jose S Pulido, Kaan Gündüz, Teresa Diago, Colin Mccannel, Christopher Blodi, Thomas Link

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To correlate fundus autofluorescence (FAF) in choroidal metastases with clinical changes overlying the lesions using confocal scanning laser ophthalmoscope. Methods: Retrospective chart review of 15 metastatic tumors in 14 eyes of 11 consecutive patients. The patients underwent confocal scanning laser ophthalmoscope to compare the clinical findings and FAF. Correlation between increased FAF and clinical changes was defined as complete, partial, or no correlation. Results: Of 11 patients, 8 (73%) were women, and the average age was 56 years. All 15 metastases were amelanotic, focal hyperpigmentation was present in 8 (53%), subretinal fluid in eleven (73%), whereas drusen and orange pigment were absent. Of 8 tumors that were visualized by scanning laser ophthalmoscope, 7 tumors (87%) showed correlation between FAF and hyperpigmentation, no correlation in 1 (13%). A complete correlation between hyperpigmentation and FAF was found in 5 (70%) tumors and a partial correlation in 2 (30%). There was partial correlation between subretinal fluid and FAF in 6 metastases (46%), no correlation in 5 (39%). Three metastases without hyperpigmentation had FAF, one showed the presence of subretinal fluid. Conclusion: Amelanotic choroidal metastases with hyperpigmentation are associated with increased FAF in most cases. Subretinal fluid overlying choroidal metastases may cause FAF as well. RETINA 28:1251-1256, 2008

Original languageEnglish (US)
Pages (from-to)1251-1256
Number of pages6
JournalRetina
Volume28
Issue number9
DOIs
StatePublished - Oct 2008

Fingerprint

Hyperpigmentation
Subretinal Fluid
Neoplasm Metastasis
Ophthalmoscopes
Lasers
Neoplasms

Keywords

  • Choroidal metastasis
  • Fundus autofluorescence
  • Heidelberg 2 scanning laser ophthalmoscopy
  • Uveal metastasis

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Collet, L. C., Pulido, J. S., Gündüz, K., Diago, T., Mccannel, C., Blodi, C., & Link, T. (2008). Fundus autofluorescence in choroidal metastatic lesions a pilot study. Retina, 28(9), 1251-1256. https://doi.org/10.1097/IAE.0b013e318188c7d0

Fundus autofluorescence in choroidal metastatic lesions a pilot study. / Collet, Lucienne C.; Pulido, Jose S; Gündüz, Kaan; Diago, Teresa; Mccannel, Colin; Blodi, Christopher; Link, Thomas.

In: Retina, Vol. 28, No. 9, 10.2008, p. 1251-1256.

Research output: Contribution to journalArticle

Collet, LC, Pulido, JS, Gündüz, K, Diago, T, Mccannel, C, Blodi, C & Link, T 2008, 'Fundus autofluorescence in choroidal metastatic lesions a pilot study', Retina, vol. 28, no. 9, pp. 1251-1256. https://doi.org/10.1097/IAE.0b013e318188c7d0
Collet LC, Pulido JS, Gündüz K, Diago T, Mccannel C, Blodi C et al. Fundus autofluorescence in choroidal metastatic lesions a pilot study. Retina. 2008 Oct;28(9):1251-1256. https://doi.org/10.1097/IAE.0b013e318188c7d0
Collet, Lucienne C. ; Pulido, Jose S ; Gündüz, Kaan ; Diago, Teresa ; Mccannel, Colin ; Blodi, Christopher ; Link, Thomas. / Fundus autofluorescence in choroidal metastatic lesions a pilot study. In: Retina. 2008 ; Vol. 28, No. 9. pp. 1251-1256.
@article{4dc60121ef5f4012901899ef5effebf9,
title = "Fundus autofluorescence in choroidal metastatic lesions a pilot study",
abstract = "Purpose: To correlate fundus autofluorescence (FAF) in choroidal metastases with clinical changes overlying the lesions using confocal scanning laser ophthalmoscope. Methods: Retrospective chart review of 15 metastatic tumors in 14 eyes of 11 consecutive patients. The patients underwent confocal scanning laser ophthalmoscope to compare the clinical findings and FAF. Correlation between increased FAF and clinical changes was defined as complete, partial, or no correlation. Results: Of 11 patients, 8 (73{\%}) were women, and the average age was 56 years. All 15 metastases were amelanotic, focal hyperpigmentation was present in 8 (53{\%}), subretinal fluid in eleven (73{\%}), whereas drusen and orange pigment were absent. Of 8 tumors that were visualized by scanning laser ophthalmoscope, 7 tumors (87{\%}) showed correlation between FAF and hyperpigmentation, no correlation in 1 (13{\%}). A complete correlation between hyperpigmentation and FAF was found in 5 (70{\%}) tumors and a partial correlation in 2 (30{\%}). There was partial correlation between subretinal fluid and FAF in 6 metastases (46{\%}), no correlation in 5 (39{\%}). Three metastases without hyperpigmentation had FAF, one showed the presence of subretinal fluid. Conclusion: Amelanotic choroidal metastases with hyperpigmentation are associated with increased FAF in most cases. Subretinal fluid overlying choroidal metastases may cause FAF as well. RETINA 28:1251-1256, 2008",
keywords = "Choroidal metastasis, Fundus autofluorescence, Heidelberg 2 scanning laser ophthalmoscopy, Uveal metastasis",
author = "Collet, {Lucienne C.} and Pulido, {Jose S} and Kaan G{\"u}nd{\"u}z and Teresa Diago and Colin Mccannel and Christopher Blodi and Thomas Link",
year = "2008",
month = "10",
doi = "10.1097/IAE.0b013e318188c7d0",
language = "English (US)",
volume = "28",
pages = "1251--1256",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Fundus autofluorescence in choroidal metastatic lesions a pilot study

AU - Collet, Lucienne C.

AU - Pulido, Jose S

AU - Gündüz, Kaan

AU - Diago, Teresa

AU - Mccannel, Colin

AU - Blodi, Christopher

AU - Link, Thomas

PY - 2008/10

Y1 - 2008/10

N2 - Purpose: To correlate fundus autofluorescence (FAF) in choroidal metastases with clinical changes overlying the lesions using confocal scanning laser ophthalmoscope. Methods: Retrospective chart review of 15 metastatic tumors in 14 eyes of 11 consecutive patients. The patients underwent confocal scanning laser ophthalmoscope to compare the clinical findings and FAF. Correlation between increased FAF and clinical changes was defined as complete, partial, or no correlation. Results: Of 11 patients, 8 (73%) were women, and the average age was 56 years. All 15 metastases were amelanotic, focal hyperpigmentation was present in 8 (53%), subretinal fluid in eleven (73%), whereas drusen and orange pigment were absent. Of 8 tumors that were visualized by scanning laser ophthalmoscope, 7 tumors (87%) showed correlation between FAF and hyperpigmentation, no correlation in 1 (13%). A complete correlation between hyperpigmentation and FAF was found in 5 (70%) tumors and a partial correlation in 2 (30%). There was partial correlation between subretinal fluid and FAF in 6 metastases (46%), no correlation in 5 (39%). Three metastases without hyperpigmentation had FAF, one showed the presence of subretinal fluid. Conclusion: Amelanotic choroidal metastases with hyperpigmentation are associated with increased FAF in most cases. Subretinal fluid overlying choroidal metastases may cause FAF as well. RETINA 28:1251-1256, 2008

AB - Purpose: To correlate fundus autofluorescence (FAF) in choroidal metastases with clinical changes overlying the lesions using confocal scanning laser ophthalmoscope. Methods: Retrospective chart review of 15 metastatic tumors in 14 eyes of 11 consecutive patients. The patients underwent confocal scanning laser ophthalmoscope to compare the clinical findings and FAF. Correlation between increased FAF and clinical changes was defined as complete, partial, or no correlation. Results: Of 11 patients, 8 (73%) were women, and the average age was 56 years. All 15 metastases were amelanotic, focal hyperpigmentation was present in 8 (53%), subretinal fluid in eleven (73%), whereas drusen and orange pigment were absent. Of 8 tumors that were visualized by scanning laser ophthalmoscope, 7 tumors (87%) showed correlation between FAF and hyperpigmentation, no correlation in 1 (13%). A complete correlation between hyperpigmentation and FAF was found in 5 (70%) tumors and a partial correlation in 2 (30%). There was partial correlation between subretinal fluid and FAF in 6 metastases (46%), no correlation in 5 (39%). Three metastases without hyperpigmentation had FAF, one showed the presence of subretinal fluid. Conclusion: Amelanotic choroidal metastases with hyperpigmentation are associated with increased FAF in most cases. Subretinal fluid overlying choroidal metastases may cause FAF as well. RETINA 28:1251-1256, 2008

KW - Choroidal metastasis

KW - Fundus autofluorescence

KW - Heidelberg 2 scanning laser ophthalmoscopy

KW - Uveal metastasis

UR - http://www.scopus.com/inward/record.url?scp=67649238253&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649238253&partnerID=8YFLogxK

U2 - 10.1097/IAE.0b013e318188c7d0

DO - 10.1097/IAE.0b013e318188c7d0

M3 - Article

VL - 28

SP - 1251

EP - 1256

JO - Retina

JF - Retina

SN - 0275-004X

IS - 9

ER -