TY - JOUR
T1 - Fundamentals of neurogastroenterology
T2 - Physiology/motility - Sensation
AU - Boeckxstaens, Guy
AU - Camilleri, Michael
AU - Sifrim, Daniel
AU - Houghton, Lesley A.
AU - Elsenbruch, Sigrid
AU - Lindberg, Greger
AU - Azpiroz, Fernando
AU - Parkman, Henry P.
N1 - Publisher Copyright:
© 2016 by the AGA Institute.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - The fundamental gastrointestinal functions include motility, sensation, absorption, secretion, digestion, and intestinal barrier function. Digestion of food and absorption of nutrients normally occurs without conscious perception. Symptoms of functional gastrointestinal disorders often are triggered by meal intake, suggesting abnormalities in the physiological processes are involved in the generation of symptoms. In this article, normal physiology and pathophysiology of gastrointestinal function, and the processes underlying symptom generation, are critically reviewed. The functions of each anatomic region of the digestive tract are summarized. The pathophysiology of perception, motility, mucosal barrier, and secretion in functional gastrointestinal disorders as well as effects of food, meal intake, and microbiota on gastrointestinal motility and sensation are discussed. Genetic mechanisms associated with visceral pain and motor functions in health and functional gastrointestinal disorders are reviewed. Understanding the basis for digestive tract functions is essential to understand dysfunctions in functional gastrointestinal disorders.
AB - The fundamental gastrointestinal functions include motility, sensation, absorption, secretion, digestion, and intestinal barrier function. Digestion of food and absorption of nutrients normally occurs without conscious perception. Symptoms of functional gastrointestinal disorders often are triggered by meal intake, suggesting abnormalities in the physiological processes are involved in the generation of symptoms. In this article, normal physiology and pathophysiology of gastrointestinal function, and the processes underlying symptom generation, are critically reviewed. The functions of each anatomic region of the digestive tract are summarized. The pathophysiology of perception, motility, mucosal barrier, and secretion in functional gastrointestinal disorders as well as effects of food, meal intake, and microbiota on gastrointestinal motility and sensation are discussed. Genetic mechanisms associated with visceral pain and motor functions in health and functional gastrointestinal disorders are reviewed. Understanding the basis for digestive tract functions is essential to understand dysfunctions in functional gastrointestinal disorders.
KW - Absorption
KW - Gastrointestinal Motility
KW - Secretion
KW - Sensation
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U2 - 10.1053/j.gastro.2016.02.030
DO - 10.1053/j.gastro.2016.02.030
M3 - Article
AN - SCOPUS:84964789955
SN - 0016-5085
VL - 150
SP - 1292-1304.e2
JO - Gastroenterology
JF - Gastroenterology
IS - 6
ER -