Functional role of KLF10 in multiple disease processes

Malayannan Subramaniam, John R. Hawse, Nalini M. Rajamannan, James N. Ingle, Thomas C. Spelsberg

Research output: Contribution to journalReview articlepeer-review

63 Scopus citations

Abstract

Since the discovery by this laboratory of the zinc finger transcription factor, KLF10, a member of the Krüppel-like family of transcription factors, there have been multiple publications regarding its functions and its immediate family members, in numerous cell types. KLF10 has been shown to be rapidly induced by TGFβ1, 2, 3, E2, epidermal growth factor, and bone morphogenetic protein-2. TGFβ inducible early gene-1 activates the TGFβ-Smad signaling pathway via repression of Smad 7 expression and activation of Smad 2 expression and activity. Overall, KLF10 has been implicated in cell differentiation, as a target gene for a variety of signaling pathways, and in serving as a potential marker for human diseases such as breast cancer, cardiac hypertrophy, and osteoporosis. Like other KLF members, KLF10 is expressed in specific cell types in numerous tissues and is known to be involved in repressing cell proliferation and inflammation as well as inducing apoptosis similar to that of TGFβ. KLF10 binds to Sp-1-GC rich DNA sequences and can activate or repress the transcription of a number of genes. Overall, KLF10 has been shown to play a major role in the TGFβ inhibition of cell proliferation and inflammation and induction of apoptosis, and its overexpression in human osteoblasts and pancreatic carcinoma cells mimics the actions of TGFβ.

Original languageEnglish (US)
Pages (from-to)8-18
Number of pages11
JournalBioFactors
Volume36
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Apoptosis
  • Bone
  • Cancer
  • Differentiation
  • Estrogen
  • Heart
  • Immune system
  • KLF10
  • Krüppel family
  • Smads
  • TGFβ
  • TGFβ inducible early gene
  • TIEG1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Clinical Biochemistry

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