Functional outcome and survival following spontaneous intracerebral hemorrhage: A retrospective population-based study

Lise R. Øie, Mattis A. Madsbu, Ole Solheim, Asgeir S. Jakola, Charalampis Giannadakis, Anders Vorhaug, Llewellyn Padayachy, Heidi Jensberg, David William Dodick, Øyvind Salvesen, Sasha Gulati

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Accurate and reliable clinical and radiological predictors of intracerebral hemorrhage (ICH) outcomes are needed to optimize treatment of ICH. The aim of this study was to investigate functional outcome and identify predictors of severe disability or death following ICH. Materials and methods: Retrospective population-based study of spontaneous ICH. Clinical and radiological data were obtained from electronic medical records, and functional outcome estimated using the modified Rankin Scale (mRS) before ICH and at 3 and 12 months after ICH. Results: Four hundred and fifty-two patients were included (mean age 74.8 years, 45.6% females). Proportion of fatal outcome at 1 week was 22.1%, at 3 months 39.2%, and at 12 months 44.9%. Median mRS score before the ICH was 1 (interquartile range [IQR] 2); for survivors at 3 months, it was 5 (IQR 3); and at 12 months, it was 3 (IQR 2). Independent predictors of severe disability (mRS of 5) or death (mRS of 6) were use of oral antithrombotic drugs (OR 2.2, 95% CI 1.3–3.8, p = 0.04), mRS score before the ICH (OR 1.8, 95% CI 1.4–2.2, p < 0.001), Glasgow Coma Scale (GCS) on admission (OR 8.3, 95% CI 3.5–19.7, p < 0.001), hematoma volume >60 ml (OR 4.5, 05% CI 2.0–10.2, p < 0.001), and intraventricular hematoma extension (OR 1.8, 95% CI 0.8–4.2, p < 0.001). Conclusion: Intracerebral hemorrhage is associated with high mortality, and more than one third of survivors end up with severe disability or death 3 months later. Predictors of severe disability or death were use of oral antithrombotic drugs, functional disability prior to ICH, low GCS on admission, larger hematoma volume, and intraventricular hematoma extension.

Original languageEnglish (US)
JournalBrain and Behavior
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Cerebral Hemorrhage
Survival
Population
Hematoma
Survivors
Fatal Outcome
Electronic Health Records
Pharmaceutical Preparations
Mortality

Keywords

  • intracerebral hemorrhage
  • outcome
  • population-based
  • predictors
  • survival

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Øie, L. R., Madsbu, M. A., Solheim, O., Jakola, A. S., Giannadakis, C., Vorhaug, A., ... Gulati, S. (Accepted/In press). Functional outcome and survival following spontaneous intracerebral hemorrhage: A retrospective population-based study. Brain and Behavior. https://doi.org/10.1002/brb3.1113

Functional outcome and survival following spontaneous intracerebral hemorrhage : A retrospective population-based study. / Øie, Lise R.; Madsbu, Mattis A.; Solheim, Ole; Jakola, Asgeir S.; Giannadakis, Charalampis; Vorhaug, Anders; Padayachy, Llewellyn; Jensberg, Heidi; Dodick, David William; Salvesen, Øyvind; Gulati, Sasha.

In: Brain and Behavior, 01.01.2018.

Research output: Contribution to journalArticle

Øie, LR, Madsbu, MA, Solheim, O, Jakola, AS, Giannadakis, C, Vorhaug, A, Padayachy, L, Jensberg, H, Dodick, DW, Salvesen, Ø & Gulati, S 2018, 'Functional outcome and survival following spontaneous intracerebral hemorrhage: A retrospective population-based study', Brain and Behavior. https://doi.org/10.1002/brb3.1113
Øie, Lise R. ; Madsbu, Mattis A. ; Solheim, Ole ; Jakola, Asgeir S. ; Giannadakis, Charalampis ; Vorhaug, Anders ; Padayachy, Llewellyn ; Jensberg, Heidi ; Dodick, David William ; Salvesen, Øyvind ; Gulati, Sasha. / Functional outcome and survival following spontaneous intracerebral hemorrhage : A retrospective population-based study. In: Brain and Behavior. 2018.
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abstract = "Background: Accurate and reliable clinical and radiological predictors of intracerebral hemorrhage (ICH) outcomes are needed to optimize treatment of ICH. The aim of this study was to investigate functional outcome and identify predictors of severe disability or death following ICH. Materials and methods: Retrospective population-based study of spontaneous ICH. Clinical and radiological data were obtained from electronic medical records, and functional outcome estimated using the modified Rankin Scale (mRS) before ICH and at 3 and 12 months after ICH. Results: Four hundred and fifty-two patients were included (mean age 74.8 years, 45.6{\%} females). Proportion of fatal outcome at 1 week was 22.1{\%}, at 3 months 39.2{\%}, and at 12 months 44.9{\%}. Median mRS score before the ICH was 1 (interquartile range [IQR] 2); for survivors at 3 months, it was 5 (IQR 3); and at 12 months, it was 3 (IQR 2). Independent predictors of severe disability (mRS of 5) or death (mRS of 6) were use of oral antithrombotic drugs (OR 2.2, 95{\%} CI 1.3–3.8, p = 0.04), mRS score before the ICH (OR 1.8, 95{\%} CI 1.4–2.2, p < 0.001), Glasgow Coma Scale (GCS) on admission (OR 8.3, 95{\%} CI 3.5–19.7, p < 0.001), hematoma volume >60 ml (OR 4.5, 05{\%} CI 2.0–10.2, p < 0.001), and intraventricular hematoma extension (OR 1.8, 95{\%} CI 0.8–4.2, p < 0.001). Conclusion: Intracerebral hemorrhage is associated with high mortality, and more than one third of survivors end up with severe disability or death 3 months later. Predictors of severe disability or death were use of oral antithrombotic drugs, functional disability prior to ICH, low GCS on admission, larger hematoma volume, and intraventricular hematoma extension.",
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T1 - Functional outcome and survival following spontaneous intracerebral hemorrhage

T2 - A retrospective population-based study

AU - Øie, Lise R.

AU - Madsbu, Mattis A.

AU - Solheim, Ole

AU - Jakola, Asgeir S.

AU - Giannadakis, Charalampis

AU - Vorhaug, Anders

AU - Padayachy, Llewellyn

AU - Jensberg, Heidi

AU - Dodick, David William

AU - Salvesen, Øyvind

AU - Gulati, Sasha

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Accurate and reliable clinical and radiological predictors of intracerebral hemorrhage (ICH) outcomes are needed to optimize treatment of ICH. The aim of this study was to investigate functional outcome and identify predictors of severe disability or death following ICH. Materials and methods: Retrospective population-based study of spontaneous ICH. Clinical and radiological data were obtained from electronic medical records, and functional outcome estimated using the modified Rankin Scale (mRS) before ICH and at 3 and 12 months after ICH. Results: Four hundred and fifty-two patients were included (mean age 74.8 years, 45.6% females). Proportion of fatal outcome at 1 week was 22.1%, at 3 months 39.2%, and at 12 months 44.9%. Median mRS score before the ICH was 1 (interquartile range [IQR] 2); for survivors at 3 months, it was 5 (IQR 3); and at 12 months, it was 3 (IQR 2). Independent predictors of severe disability (mRS of 5) or death (mRS of 6) were use of oral antithrombotic drugs (OR 2.2, 95% CI 1.3–3.8, p = 0.04), mRS score before the ICH (OR 1.8, 95% CI 1.4–2.2, p < 0.001), Glasgow Coma Scale (GCS) on admission (OR 8.3, 95% CI 3.5–19.7, p < 0.001), hematoma volume >60 ml (OR 4.5, 05% CI 2.0–10.2, p < 0.001), and intraventricular hematoma extension (OR 1.8, 95% CI 0.8–4.2, p < 0.001). Conclusion: Intracerebral hemorrhage is associated with high mortality, and more than one third of survivors end up with severe disability or death 3 months later. Predictors of severe disability or death were use of oral antithrombotic drugs, functional disability prior to ICH, low GCS on admission, larger hematoma volume, and intraventricular hematoma extension.

AB - Background: Accurate and reliable clinical and radiological predictors of intracerebral hemorrhage (ICH) outcomes are needed to optimize treatment of ICH. The aim of this study was to investigate functional outcome and identify predictors of severe disability or death following ICH. Materials and methods: Retrospective population-based study of spontaneous ICH. Clinical and radiological data were obtained from electronic medical records, and functional outcome estimated using the modified Rankin Scale (mRS) before ICH and at 3 and 12 months after ICH. Results: Four hundred and fifty-two patients were included (mean age 74.8 years, 45.6% females). Proportion of fatal outcome at 1 week was 22.1%, at 3 months 39.2%, and at 12 months 44.9%. Median mRS score before the ICH was 1 (interquartile range [IQR] 2); for survivors at 3 months, it was 5 (IQR 3); and at 12 months, it was 3 (IQR 2). Independent predictors of severe disability (mRS of 5) or death (mRS of 6) were use of oral antithrombotic drugs (OR 2.2, 95% CI 1.3–3.8, p = 0.04), mRS score before the ICH (OR 1.8, 95% CI 1.4–2.2, p < 0.001), Glasgow Coma Scale (GCS) on admission (OR 8.3, 95% CI 3.5–19.7, p < 0.001), hematoma volume >60 ml (OR 4.5, 05% CI 2.0–10.2, p < 0.001), and intraventricular hematoma extension (OR 1.8, 95% CI 0.8–4.2, p < 0.001). Conclusion: Intracerebral hemorrhage is associated with high mortality, and more than one third of survivors end up with severe disability or death 3 months later. Predictors of severe disability or death were use of oral antithrombotic drugs, functional disability prior to ICH, low GCS on admission, larger hematoma volume, and intraventricular hematoma extension.

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