Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis

Michael Blaber; Hyesook Yoon; Maria A. Juliano; Isobel A. Scarisbrick; Sachiko I. Blaber

doi:10.1515/BC.2010.024

Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis

Michael Blaber, Hyesook Yoon, Maria A. Juliano, Isobel A. Scarisbrick, Sachiko I. Blaber

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.

Original language	English (US)
Pages (from-to)	311-320
Number of pages	10
Journal	Biological Chemistry
Volume	391
Issue number	4
DOIs	https://doi.org/10.1515/BC.2010.024
State	Published - Apr 1 2010

Keywords

Activation cascade
Kallikrein
Kallikrein-related peptidase (KLK)
Plasmin
Thrombogenesis
Thrombolysis
Thrombostasis

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Clinical Biochemistry

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10.1515/BC.2010.024

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abstract = "A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.",

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AU - Yoon, Hyesook

AU - Juliano, Maria A.

AU - Scarisbrick, Isobel A.

AU - Blaber, Sachiko I.

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AB - A large body of emerging evidence indicates a functional interaction between the kallikrein-related peptidases (KLKs) and proteases of the thrombostasis axis. These interactions appear relevant for both normal health as well as pathologies associated with inflammation, tissue injury, and remodeling. Regulatory interactions between the KLKs and thrombostasis proteases could impact several serious human diseases, including neurodegeneration and cancer. The emerging network of specific interactions between these two protease families appears to be complex, and much work remains to elucidate it. Complete understanding how this functional network resolves over time, given specific initial conditions, and how it might be controllably manipulated, will probably contribute to the emergence of novel diagnostics and therapeutic agents for major diseases.

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Functional intersection of the kallikrein-related peptidases (KLKs) and thrombostasis axis

Abstract

Keywords

ASJC Scopus subject areas

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