Functional hypothalamic amenorrhea

An endocrine society clinical practice guideline

Catherine M. Gordon, Kathryn E. Ackerman, Sarah L. Berga, Jay R. Kaplan, George Mastorakos, Madhusmita Misra, Mohammad H Murad, Nanette F. Santoro, Michelle P. Warren

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Cosponsoring Associations: The American Society for Reproductive Medicine, the European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. Objective: To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). Participants: The participants include an Endocrine Society-appointed task force of eight experts, a methodologist, and a medical writer. Evidence: This evidence-based guidelinewas developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence. The task force commissioned two systematic reviews and used the best available evidence from other published systematic reviews and individual studies. Consensus Process: One group meeting, several conference calls, and e-mail communications enabled consensus. Endocrine Society committees and members and cosponsoring organizations reviewed and commented on preliminary drafts of this guideline. Conclusions: FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. Investigations should include assessment of systemic and endocrinologic etiologies, as FHA is a diagnosis of exclusion. A multidisciplinary treatment approach is necessary, including medical, dietary, and mental health support. Medical complications include, among others, bone loss and infertility, and appropriate therapies are under debate and investigation. (J Clin Endocrinol Metab 102: 1413-1439, 2017).

Original languageEnglish (US)
Pages (from-to)1413-1439
Number of pages27
JournalJournal of Clinical Endocrinology and Metabolism
Volume102
Issue number5
DOIs
StatePublished - May 1 2017

Fingerprint

Amenorrhea
Practice Guidelines
Advisory Committees
Teleconferencing
Pediatrics
Consensus
Guidelines
Committee Membership
Anovulation
Bone
Group Processes
Health
Postal Service
Infertility
Weight Loss
Communication
Mental Health
Organizations
Bone and Bones
Therapeutics

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Gordon, C. M., Ackerman, K. E., Berga, S. L., Kaplan, J. R., Mastorakos, G., Misra, M., ... Warren, M. P. (2017). Functional hypothalamic amenorrhea: An endocrine society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism, 102(5), 1413-1439. https://doi.org/10.1210/jc.2017-00131

Functional hypothalamic amenorrhea : An endocrine society clinical practice guideline. / Gordon, Catherine M.; Ackerman, Kathryn E.; Berga, Sarah L.; Kaplan, Jay R.; Mastorakos, George; Misra, Madhusmita; Murad, Mohammad H; Santoro, Nanette F.; Warren, Michelle P.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 102, No. 5, 01.05.2017, p. 1413-1439.

Research output: Contribution to journalArticle

Gordon, CM, Ackerman, KE, Berga, SL, Kaplan, JR, Mastorakos, G, Misra, M, Murad, MH, Santoro, NF & Warren, MP 2017, 'Functional hypothalamic amenorrhea: An endocrine society clinical practice guideline', Journal of Clinical Endocrinology and Metabolism, vol. 102, no. 5, pp. 1413-1439. https://doi.org/10.1210/jc.2017-00131
Gordon, Catherine M. ; Ackerman, Kathryn E. ; Berga, Sarah L. ; Kaplan, Jay R. ; Mastorakos, George ; Misra, Madhusmita ; Murad, Mohammad H ; Santoro, Nanette F. ; Warren, Michelle P. / Functional hypothalamic amenorrhea : An endocrine society clinical practice guideline. In: Journal of Clinical Endocrinology and Metabolism. 2017 ; Vol. 102, No. 5. pp. 1413-1439.
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