Functional genomics based on germline genome-wide association studies of endocrine therapy for breast cancer

Jacqueline Zayas, Sisi Qin, Jia Yu, James Newell Ingle, Liewei Wang

Research output: Contribution to journalReview article

Abstract

Breast cancer is the most common invasive cancer in women worldwide. Functional follow-up of breast cancer genome-wide association studies has led to the discovery of genes that regulate endocrine therapy response in a SNP- and drug-dependent manner. Here, we will present four examples in which functional genomic studies from breast cancer clinical trials led to novel pharmacogenomic insights and molecular mechanisms of selective estrogen receptor modulators and aromatase inhibitors. The approach utilized for studying genetic variability described in this review offers substantial potential for meaningful discoveries that move the field toward precision medicine for patients.

Original languageEnglish (US)
Pages (from-to)615-625
Number of pages11
JournalPharmacogenomics
Volume21
Issue number9
DOIs
StatePublished - Jun 2020

Keywords

  • breast cancer
  • endocrine therapy
  • functional genomics
  • GWAS
  • SNP

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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