Abstract
Emerging cancer therapies target signaling networks that are overexpressed in cancers. We have developed a phosphoprotein detection panel mapped around the PI3K/Akt/mTOR signaling cascade using microring resonator arrays. We used the panel to monitor signaling dynamics in response to treatment with targeted therapeutics on xenograft explants of glioblastoma tumors. Distinct phosphoprotein profiles were observed as a function of mutational status of the xenograft samples, and the extent of pathway inhibition was dependent on treatment times. This panel detection technology offers substantially higher throughput than global pathway monitoring techniques, such as mass spectrometry-based proteomics or next generation sequencing.
| Original language | English (US) |
|---|---|
| Title of host publication | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1289-1290 |
| Number of pages | 2 |
| ISBN (Electronic) | 9780692941836 |
| State | Published - Jan 1 2020 |
| Event | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: Oct 22 2017 → Oct 26 2017 |
Publication series
| Name | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
|---|
Conference
| Conference | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
|---|---|
| Country | United States |
| City | Savannah |
| Period | 10/22/17 → 10/26/17 |
Keywords
- Microring resonators
- Precision medicine
- Protein detection
- Silicon photonics
ASJC Scopus subject areas
- Chemical Engineering (miscellaneous)
- Bioengineering
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Cite this
Wade, J. H., Sarkaria, J. N., & Bailey, R. C. (2020). Functional diagnostics for precision medicine with silicon photonic microring resonator arrays. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1289-1290). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.