Functional diagnostics for precision medicine with silicon photonic microring resonator arrays

James H. Wade, Jann N. Sarkaria, Ryan C. Bailey

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Emerging cancer therapies target signaling networks that are overexpressed in cancers. We have developed a phosphoprotein detection panel mapped around the PI3K/Akt/mTOR signaling cascade using microring resonator arrays. We used the panel to monitor signaling dynamics in response to treatment with targeted therapeutics on xenograft explants of glioblastoma tumors. Distinct phosphoprotein profiles were observed as a function of mutational status of the xenograft samples, and the extent of pathway inhibition was dependent on treatment times. This panel detection technology offers substantially higher throughput than global pathway monitoring techniques, such as mass spectrometry-based proteomics or next generation sequencing.

Original languageEnglish (US)
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1289-1290
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - Jan 1 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

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Keywords

  • Microring resonators
  • Precision medicine
  • Protein detection
  • Silicon photonics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering

Cite this

Wade, J. H., Sarkaria, J. N., & Bailey, R. C. (2020). Functional diagnostics for precision medicine with silicon photonic microring resonator arrays. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1289-1290). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.