The organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.
|Original language||English (US)|
|Number of pages||9|
|Journal||Trends in Cell Biology|
|State||Published - Nov 2003|
ASJC Scopus subject areas
- Cell Biology