Functional architecture of the nucleus: Organizing the regulatory machinery for gene expression, replication and repair

Gary S. Stein, Sayyed K. Zaidi, Corey D. Braastad, Martin Montecino, Andre J. Van Wijnen, Je Yong Choi, Janet L. Stein, Jane B. Lian, Amjad Javed

Research output: Contribution to journalReview articlepeer-review

105 Scopus citations

Abstract

The organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.

Original languageEnglish (US)
Pages (from-to)584-592
Number of pages9
JournalTrends in Cell Biology
Volume13
Issue number11
DOIs
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Cell Biology

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