Functional architecture of the nucleus: Organizing the regulatory machinery for gene expression, replication and repair

Gary S. Stein, Sayyed K. Zaidi, Corey D. Braastad, Martin Montecino, Andre J. Van Wijnen, Je Yong Choi, Janet L. Stein, Jane B. Lian, Amjad Javed

Research output: Contribution to journalReview article

101 Scopus citations

Abstract

The organization and sorting of regulatory information for transcription, replication and repair depends on components of nuclear architecture. It is necessary, therefore, to understand cellular processes within the context of intranuclear microenvironments that mediate the focal assembly of the machinery for transcription, replication and repair and which facilitate the orchestration of these essential processes. Here, we discuss how nuclear anatomy supports the temporal and spatial coordination of regulatory protein recruitment for combinatorial control.

Original languageEnglish (US)
Pages (from-to)584-592
Number of pages9
JournalTrends in Cell Biology
Volume13
Issue number11
DOIs
StatePublished - Nov 2003

ASJC Scopus subject areas

  • Cell Biology

Fingerprint Dive into the research topics of 'Functional architecture of the nucleus: Organizing the regulatory machinery for gene expression, replication and repair'. Together they form a unique fingerprint.

  • Cite this

    Stein, G. S., Zaidi, S. K., Braastad, C. D., Montecino, M., Van Wijnen, A. J., Choi, J. Y., Stein, J. L., Lian, J. B., & Javed, A. (2003). Functional architecture of the nucleus: Organizing the regulatory machinery for gene expression, replication and repair. Trends in Cell Biology, 13(11), 584-592. https://doi.org/10.1016/j.tcb.2003.09.009