TY - JOUR
T1 - Functional and cognitive outcome in prolonged refractory status epilepticus
AU - Cooper, Alex D.
AU - Britton, Jeffrey W.
AU - Rabinstein, Alejandro A.
PY - 2009/12
Y1 - 2009/12
N2 - Objective: To determine the functional and cognitive outcomes of patients with prolonged refractory status epilepticus (PRSE) lasting 7 or more days despite the use of anesthetic agents for seizure suppression. Design: Retrospective analysis. Setting: St Mary's Hospital, Mayo Clinic, Rochester, Minnesota. Participants: Fourteen patients with PRSE. Intervention: Hospital follow-up interview. Main Outcome Measures: Survival rate of PRSE and functional and cognitive outcome of surviving patients based on the modified Rankin Scale (mRS) and Telephone Interview for Cognitive Status (TICS). Results: Forty-three percent of patients (6 of 14) died during hospitalization for PRSE, and 57% (8 of 14) had died by the last follow-up. Of the 6 surviving patients, 4 showed improvement and 2 showed no change in mRS score (median mRS change,-1; range, 0 to -3). Owing to preexisting cognitive deficits, 1 patient could not complete the TICS. The 5 remaining patients scored a median of 34 on the TICS (range, 30-37; reference TICS score, ≥31; maximum TICS score,41). Age, sex, PRSE duration, and etiology were not associated with chance of survival. Conclusions: Despite the high mortality rate, survival with meaningful functional and cognitive recovery is possible after PRSE. Prolonged duration of status epilepticus alone should not be considered a reason to discontinue treatment.
AB - Objective: To determine the functional and cognitive outcomes of patients with prolonged refractory status epilepticus (PRSE) lasting 7 or more days despite the use of anesthetic agents for seizure suppression. Design: Retrospective analysis. Setting: St Mary's Hospital, Mayo Clinic, Rochester, Minnesota. Participants: Fourteen patients with PRSE. Intervention: Hospital follow-up interview. Main Outcome Measures: Survival rate of PRSE and functional and cognitive outcome of surviving patients based on the modified Rankin Scale (mRS) and Telephone Interview for Cognitive Status (TICS). Results: Forty-three percent of patients (6 of 14) died during hospitalization for PRSE, and 57% (8 of 14) had died by the last follow-up. Of the 6 surviving patients, 4 showed improvement and 2 showed no change in mRS score (median mRS change,-1; range, 0 to -3). Owing to preexisting cognitive deficits, 1 patient could not complete the TICS. The 5 remaining patients scored a median of 34 on the TICS (range, 30-37; reference TICS score, ≥31; maximum TICS score,41). Age, sex, PRSE duration, and etiology were not associated with chance of survival. Conclusions: Despite the high mortality rate, survival with meaningful functional and cognitive recovery is possible after PRSE. Prolonged duration of status epilepticus alone should not be considered a reason to discontinue treatment.
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U2 - 10.1001/archneurol.2009.273
DO - 10.1001/archneurol.2009.273
M3 - Article
C2 - 20008655
AN - SCOPUS:73549094220
SN - 0003-9942
VL - 66
SP - 1505
EP - 1509
JO - Archives of neurology
JF - Archives of neurology
IS - 12
ER -