TY - JOUR
T1 - Functional anatomy and pathophysiologic principles in mitral regurgitation
T2 - Non-invasive assessment
AU - Maréchaux, Sylvestre
AU - Illman, Jeffery E.
AU - Huynh, James
AU - Michelena, Hector I.
AU - Nkomo, Vuyisile T.
AU - Tribouilloy, Christophe
N1 - Publisher Copyright:
© 2017 Anesthesia History Association
PY - 2017/11
Y1 - 2017/11
N2 - Mitral regurgitation (MR) is the most prevalent cause of valvular heart disease (VHD) in western countries. In the Euro Heart Survey on VHD, MR was the second most common heart VHD requiring surgery. It is also the most common form of VHD in community and population-based studies from the United States. The categorization of MR based on causes and mechanisms is a major determinant of clinical outcome, of possible therapies for the MR and of the effectiveness of these therapies. Surgical mitral valve (MV) repair has been shown to improve survival in patients with severe primary MR compared with MV replacement. In addition, new percutaneous repair and replacement procedures have been recently developed. Hence, accurate understanding of the functional anatomy of the MV and the pathophysiologic principles underlying MR is needed to appropriately target valve lesions. Recent advances in cardiac imaging have allowed to deeply strengthen the knowledge of the function of the MV. The present review aims at describing the functional anatomy and pathophysiology of MR through different cardiac imaging modalities.
AB - Mitral regurgitation (MR) is the most prevalent cause of valvular heart disease (VHD) in western countries. In the Euro Heart Survey on VHD, MR was the second most common heart VHD requiring surgery. It is also the most common form of VHD in community and population-based studies from the United States. The categorization of MR based on causes and mechanisms is a major determinant of clinical outcome, of possible therapies for the MR and of the effectiveness of these therapies. Surgical mitral valve (MV) repair has been shown to improve survival in patients with severe primary MR compared with MV replacement. In addition, new percutaneous repair and replacement procedures have been recently developed. Hence, accurate understanding of the functional anatomy of the MV and the pathophysiologic principles underlying MR is needed to appropriately target valve lesions. Recent advances in cardiac imaging have allowed to deeply strengthen the knowledge of the function of the MV. The present review aims at describing the functional anatomy and pathophysiology of MR through different cardiac imaging modalities.
KW - Echocardiography
KW - Mitral regurgitation
KW - Mitral valve
KW - Valvular heart disease
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U2 - 10.1016/j.pcad.2017.11.008
DO - 10.1016/j.pcad.2017.11.008
M3 - Review article
C2 - 29196230
AN - SCOPUS:85037657132
SN - 0033-0620
VL - 60
SP - 289
EP - 304
JO - Progress in Cardiovascular Diseases
JF - Progress in Cardiovascular Diseases
IS - 3
ER -