Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries

Mario Gössl, Michael Rosol, Nasser M. Malyar, Lorraine A. Fitzpatrick, Patricia E. Beighley, Mair Zamir, Erik L. Ritman

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

In this study vasa vasorum in the walls of porcine coronary arteries were examined, using three-dimensional (3D) micro-CT scanning techniques. These techniques leave the 3D structure of the vasa vasorum tree intact and thus provide a much more direct view of this structure than is possible from conventional histological sections. The study demonstrates-for the first time, we believe-both the different types and the fine architecture of these vasa vasorum. Furthermore, with the use of automated tree analysis software, it was possible to obtain quantitative geometrical data on the 3D structure of vasa vasorum trees that have not previously been available. The results indicate that despite the restrictive topology of the space in which they are present, the branching architecture of the vasa vasorum trees, which we surveyed, is surprisingly similar to that of vasculature in general. The volume of vessel wall tissue perfused or drained by a vasa vasorum tree was found to correlate well with the cross-sectional area of the root segment of the vasa vasorum tree, and the luminal surface area corresponding to this volume was found to be comparable with the surface area of an early atherosclerotic lesion. This is consistent with earlier findings that the ligation or removal of vasa vasorum leads to atherogenesis.

Original languageEnglish (US)
Pages (from-to)526-537
Number of pages12
JournalAnatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology
Volume272
Issue number2
StatePublished - Jun 1 2003

Fingerprint

Vasa Vasorum
coronary vessels
hemodynamics
anatomy
Anatomy
Coronary Vessels
Swine
Hemodynamics
swine
surface area
micro-computed tomography
atherogenesis
lesions (plant)
lesion
topology
branching
vessel
software
Ligation
Atherosclerosis

Keywords

  • Vasa vasorum
  • Vascular branching structure
  • Vascular disease
  • Vessel wall perfusion

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Anatomy

Cite this

Gössl, M., Rosol, M., Malyar, N. M., Fitzpatrick, L. A., Beighley, P. E., Zamir, M., & Ritman, E. L. (2003). Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries. Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, 272(2), 526-537.

Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries. / Gössl, Mario; Rosol, Michael; Malyar, Nasser M.; Fitzpatrick, Lorraine A.; Beighley, Patricia E.; Zamir, Mair; Ritman, Erik L.

In: Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology, Vol. 272, No. 2, 01.06.2003, p. 526-537.

Research output: Contribution to journalArticle

Gössl, Mario ; Rosol, Michael ; Malyar, Nasser M. ; Fitzpatrick, Lorraine A. ; Beighley, Patricia E. ; Zamir, Mair ; Ritman, Erik L. / Functional anatomy and hemodynamic characteristics of vasa vasorum in the walls of porcine coronary arteries. In: Anatomical Record - Part A Discoveries in Molecular, Cellular, and Evolutionary Biology. 2003 ; Vol. 272, No. 2. pp. 526-537.
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