Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators

Sarah R. Wessel, Kareem N. Mohni, Jessica W. Luzwick, Huzefa Dungrawala, David Cortez

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Wessel et al. use iPOND purifications and loss-of-function analyses to identify and characterize a replication fork and nascent chromatin proteome of 593 proteins. They demonstrate the resource's utility by showing that the BET proteins BRD2, BRD3, and BRD4 inhibit ATAD5-dependent PCNA unloading from chromatin.

Original languageEnglish (US)
Pages (from-to)3497-3509.e4
JournalCell reports
Volume28
Issue number13
DOIs
StatePublished - Sep 24 2019

Keywords

  • ATAD5
  • BET domain
  • DNA replication
  • PCNA
  • chromatin
  • iPOND
  • proteomics
  • replisome

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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