Functional ability correlates with cognitive impairment in Parkinson's disease and Alzheimer's disease

M. N. Sabbagh, T. Lahti, D. J. Connor, J. N. Caviness, H. Shill, L. Vedders, P. Mahant, J. Samanta, R. S. Burns, V. G.H. Evidente, E. Driver-Dunckley, B. Reisberg, S. Bircea, C. H. Adler

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background/Aims: Previously we have shown that functional declines in Parkinson's disease (PD) and Alzheimer's disease (AD) correlate to global measures of cognitive decline. We now determine if the correlation between cognitive impairment and functional ability in PD is similar to that in AD using individual cognitive measures. Methods: 93 PD subjects and 124 AD/MCI subjects underwent the Functional Assessment Staging (FAST), the Global Deterioration Scale (GDS), and a neuropsychological battery. Results: In PD subjects, the FAST and GDS correlated significantly with Rey Auditory Verbal Learning Test (AVLT), Controlled Oral Word Association (COWA), Animal Fluency, and Stroop but not with Clock Draw or Judgment Line Orientation (JLO). In AD/MCI subjects, FAST and GDS correlated with all neuropsychological components except Stroop. In the AD/MCI group, the UPDRS significantly correlated with the FAST, GDS, MMSE, and all neuropsychological parameters except the Stroop. In the PD group, the motor UPDRS significantly correlated significantly with FAST, GDS, MMSE and all neuropsychological parameters except Digit Span, Stroop, Clock Draw and JLO. Conclusions: Similar to AD, functional decline in PD correlates with multiple measures of cognitive impairment. Some differences between PD and AD may be explained by the influence of motor disability and declines in visuospatial function in PD.

Original languageEnglish (US)
Pages (from-to)327-334
Number of pages8
JournalDementia and geriatric cognitive disorders
Volume24
Issue number5
DOIs
StatePublished - Oct 1 2007

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Keywords

  • Alzheimer's disease
  • Cognition and function, correlation
  • Cognitive decline/impairment
  • Functional abilities
  • Functional impairment
  • Parkinson's disease

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health

Cite this

Sabbagh, M. N., Lahti, T., Connor, D. J., Caviness, J. N., Shill, H., Vedders, L., Mahant, P., Samanta, J., Burns, R. S., Evidente, V. G. H., Driver-Dunckley, E., Reisberg, B., Bircea, S., & Adler, C. H. (2007). Functional ability correlates with cognitive impairment in Parkinson's disease and Alzheimer's disease. Dementia and geriatric cognitive disorders, 24(5), 327-334. https://doi.org/10.1159/000108340