Functional ability correlates with cognitive impairment in Parkinson's disease and Alzheimer's disease

M. N. Sabbagh, T. Lahti, D. J. Connor, John Nathaniel Caviness, H. Shill, L. Vedders, P. Mahant, J. Samanta, R. S. Burns, V. G H Evidente, Erika M Driver-Dunckley, B. Reisberg, S. Bircea, Charles Howard Adler

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background/Aims: Previously we have shown that functional declines in Parkinson's disease (PD) and Alzheimer's disease (AD) correlate to global measures of cognitive decline. We now determine if the correlation between cognitive impairment and functional ability in PD is similar to that in AD using individual cognitive measures. Methods: 93 PD subjects and 124 AD/MCI subjects underwent the Functional Assessment Staging (FAST), the Global Deterioration Scale (GDS), and a neuropsychological battery. Results: In PD subjects, the FAST and GDS correlated significantly with Rey Auditory Verbal Learning Test (AVLT), Controlled Oral Word Association (COWA), Animal Fluency, and Stroop but not with Clock Draw or Judgment Line Orientation (JLO). In AD/MCI subjects, FAST and GDS correlated with all neuropsychological components except Stroop. In the AD/MCI group, the UPDRS significantly correlated with the FAST, GDS, MMSE, and all neuropsychological parameters except the Stroop. In the PD group, the motor UPDRS significantly correlated significantly with FAST, GDS, MMSE and all neuropsychological parameters except Digit Span, Stroop, Clock Draw and JLO. Conclusions: Similar to AD, functional decline in PD correlates with multiple measures of cognitive impairment. Some differences between PD and AD may be explained by the influence of motor disability and declines in visuospatial function in PD.

Original languageEnglish (US)
Pages (from-to)327-334
Number of pages8
JournalDementia and Geriatric Cognitive Disorders
Volume24
Issue number5
DOIs
StatePublished - Oct 2007

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Aptitude
Parkinson Disease
Alzheimer Disease
Verbal Learning
Cognitive Dysfunction

Keywords

  • Alzheimer's disease
  • Cognition and function, correlation
  • Cognitive decline/impairment
  • Functional abilities
  • Functional impairment
  • Parkinson's disease

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Functional ability correlates with cognitive impairment in Parkinson's disease and Alzheimer's disease. / Sabbagh, M. N.; Lahti, T.; Connor, D. J.; Caviness, John Nathaniel; Shill, H.; Vedders, L.; Mahant, P.; Samanta, J.; Burns, R. S.; Evidente, V. G H; Driver-Dunckley, Erika M; Reisberg, B.; Bircea, S.; Adler, Charles Howard.

In: Dementia and Geriatric Cognitive Disorders, Vol. 24, No. 5, 10.2007, p. 327-334.

Research output: Contribution to journalArticle

Sabbagh, MN, Lahti, T, Connor, DJ, Caviness, JN, Shill, H, Vedders, L, Mahant, P, Samanta, J, Burns, RS, Evidente, VGH, Driver-Dunckley, EM, Reisberg, B, Bircea, S & Adler, CH 2007, 'Functional ability correlates with cognitive impairment in Parkinson's disease and Alzheimer's disease', Dementia and Geriatric Cognitive Disorders, vol. 24, no. 5, pp. 327-334. https://doi.org/10.1159/000108340
Sabbagh, M. N. ; Lahti, T. ; Connor, D. J. ; Caviness, John Nathaniel ; Shill, H. ; Vedders, L. ; Mahant, P. ; Samanta, J. ; Burns, R. S. ; Evidente, V. G H ; Driver-Dunckley, Erika M ; Reisberg, B. ; Bircea, S. ; Adler, Charles Howard. / Functional ability correlates with cognitive impairment in Parkinson's disease and Alzheimer's disease. In: Dementia and Geriatric Cognitive Disorders. 2007 ; Vol. 24, No. 5. pp. 327-334.
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AU - Connor, D. J.

AU - Caviness, John Nathaniel

AU - Shill, H.

AU - Vedders, L.

AU - Mahant, P.

AU - Samanta, J.

AU - Burns, R. S.

AU - Evidente, V. G H

AU - Driver-Dunckley, Erika M

AU - Reisberg, B.

AU - Bircea, S.

AU - Adler, Charles Howard

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