TY - JOUR
T1 - Functional ability correlates with cognitive impairment in Parkinson's disease and Alzheimer's disease
AU - Sabbagh, M. N.
AU - Lahti, T.
AU - Connor, D. J.
AU - Caviness, J. N.
AU - Shill, H.
AU - Vedders, L.
AU - Mahant, P.
AU - Samanta, J.
AU - Burns, R. S.
AU - Evidente, V. G.H.
AU - Driver-Dunckley, E.
AU - Reisberg, B.
AU - Bircea, S.
AU - Adler, C. H.
PY - 2007/10
Y1 - 2007/10
N2 - Background/Aims: Previously we have shown that functional declines in Parkinson's disease (PD) and Alzheimer's disease (AD) correlate to global measures of cognitive decline. We now determine if the correlation between cognitive impairment and functional ability in PD is similar to that in AD using individual cognitive measures. Methods: 93 PD subjects and 124 AD/MCI subjects underwent the Functional Assessment Staging (FAST), the Global Deterioration Scale (GDS), and a neuropsychological battery. Results: In PD subjects, the FAST and GDS correlated significantly with Rey Auditory Verbal Learning Test (AVLT), Controlled Oral Word Association (COWA), Animal Fluency, and Stroop but not with Clock Draw or Judgment Line Orientation (JLO). In AD/MCI subjects, FAST and GDS correlated with all neuropsychological components except Stroop. In the AD/MCI group, the UPDRS significantly correlated with the FAST, GDS, MMSE, and all neuropsychological parameters except the Stroop. In the PD group, the motor UPDRS significantly correlated significantly with FAST, GDS, MMSE and all neuropsychological parameters except Digit Span, Stroop, Clock Draw and JLO. Conclusions: Similar to AD, functional decline in PD correlates with multiple measures of cognitive impairment. Some differences between PD and AD may be explained by the influence of motor disability and declines in visuospatial function in PD.
AB - Background/Aims: Previously we have shown that functional declines in Parkinson's disease (PD) and Alzheimer's disease (AD) correlate to global measures of cognitive decline. We now determine if the correlation between cognitive impairment and functional ability in PD is similar to that in AD using individual cognitive measures. Methods: 93 PD subjects and 124 AD/MCI subjects underwent the Functional Assessment Staging (FAST), the Global Deterioration Scale (GDS), and a neuropsychological battery. Results: In PD subjects, the FAST and GDS correlated significantly with Rey Auditory Verbal Learning Test (AVLT), Controlled Oral Word Association (COWA), Animal Fluency, and Stroop but not with Clock Draw or Judgment Line Orientation (JLO). In AD/MCI subjects, FAST and GDS correlated with all neuropsychological components except Stroop. In the AD/MCI group, the UPDRS significantly correlated with the FAST, GDS, MMSE, and all neuropsychological parameters except the Stroop. In the PD group, the motor UPDRS significantly correlated significantly with FAST, GDS, MMSE and all neuropsychological parameters except Digit Span, Stroop, Clock Draw and JLO. Conclusions: Similar to AD, functional decline in PD correlates with multiple measures of cognitive impairment. Some differences between PD and AD may be explained by the influence of motor disability and declines in visuospatial function in PD.
KW - Alzheimer's disease
KW - Cognition and function, correlation
KW - Cognitive decline/impairment
KW - Functional abilities
KW - Functional impairment
KW - Parkinson's disease
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U2 - 10.1159/000108340
DO - 10.1159/000108340
M3 - Article
C2 - 17851237
AN - SCOPUS:35648964288
SN - 1420-8008
VL - 24
SP - 327
EP - 334
JO - Dementia and geriatric cognitive disorders
JF - Dementia and geriatric cognitive disorders
IS - 5
ER -