Fulminant hepatitis

Mayo clinic experience with 34 cases

Jorge Rakela, S. M. Lange, J. Ludwig, W. P. Baldus

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

From 1974 through 1982, fulminant hepatitis was diagnosed in 34 patients at our institution. Of these patients, only two survived (survival rate, 6%). This syndrome was caused by viruses (B and non-B hepatitis and herpes simplex) in 23 patients, hepatotoxic drugs in 6, Wilson's disease (hepatolenticular degeneration) in 3, and industrial poisons in 2. Most of the patients died within 10 days after the onset of encephalopathy. The poor prognosis in our group of patients was probably related to the preponderance of older patients and cases caused by non-B hepatitis virus. In our patients, the clinical course was complicated by renal failure, ascites, bleeding, sepsis, pancreatitis, and seizures. The major cause of death was hepatic failure.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalMayo Clinic Proceedings
Volume60
Issue number5
StatePublished - 1985

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Hepatitis
Hepatolenticular Degeneration
Cercopithecine Herpesvirus 1
Hepatitis Viruses
Herpes Simplex
Poisons
Liver Failure
Brain Diseases
Ascites
Pancreatitis
Renal Insufficiency
Cause of Death
Sepsis
Seizures
Survival Rate
Hemorrhage
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Rakela, J., Lange, S. M., Ludwig, J., & Baldus, W. P. (1985). Fulminant hepatitis: Mayo clinic experience with 34 cases. Mayo Clinic Proceedings, 60(5), 289-292.

Fulminant hepatitis : Mayo clinic experience with 34 cases. / Rakela, Jorge; Lange, S. M.; Ludwig, J.; Baldus, W. P.

In: Mayo Clinic Proceedings, Vol. 60, No. 5, 1985, p. 289-292.

Research output: Contribution to journalArticle

Rakela, J, Lange, SM, Ludwig, J & Baldus, WP 1985, 'Fulminant hepatitis: Mayo clinic experience with 34 cases', Mayo Clinic Proceedings, vol. 60, no. 5, pp. 289-292.
Rakela, Jorge ; Lange, S. M. ; Ludwig, J. ; Baldus, W. P. / Fulminant hepatitis : Mayo clinic experience with 34 cases. In: Mayo Clinic Proceedings. 1985 ; Vol. 60, No. 5. pp. 289-292.
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