Fulminant hepatitis B virus: Recurrence after liver transplantation in two patients also infected with hepatitis delta virus

Willem A. Marsman, Russell H. Wiesner, Kenneth P. Batts, John J. Poterucha, Michael K. Porayko, H. G M Niesters, Pieter E. Zondervan, R. A F Krom

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Liver transplantation for hepatitis B virus (HBV)-related liver disease is complicated by HBV recurrence and, consequently, poor patient and graft survival. Patients transplanted for hepatitis delta virus (HDV)-related cirrhosis are reported to have a diminished incidence of HBV recurrence and improved graft survival. However, only a few reported HDV-infected patients had active HBV replicative disease before liver transplantation. In our experience, we transplanted two HDV-infected patients, both of whom had active HBV replication before liver transplantation. In one patient, hepatitis B surface antigen (HBsAg) recurred four months after transplantation. Two months later, Hepatitis Be antigen (HBeAg) and HBV-DNA became positive, and the patient died of fulminant recurrent hepatitis B and hepatitis delta. In the other patient, HBV persisted after transplantation, and 2 months later the patient required retransplantation for fulminant recurrent hepatitis B and hepatitis delta. With the second graft, the patient remained free of HBV infection for 1 year. Thereafter, the patient experienced HBV recurrence with active replication and died of fulminant hepatitis B and delta recurrence. In the first ease and in the second graft of the second case, hepatitis B immunoglobulin (HBIG) immunoprophylaxis was administered in an attempt to prevent recurrence of HBV. The literature suggests that an HDV infection inhibits the replication of HBV and therefore plays a role in preventing the recurrence of HBV and improving survival. Our experience with two patients suggests that HDV infection, in the presence of active HBV replication, may not play a protective role.

Original languageEnglish (US)
Pages (from-to)434-438
Number of pages5
JournalHepatology
Volume25
Issue number2
StatePublished - Feb 1997

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Hepatitis Delta Virus
Hepatitis B virus
Liver Transplantation
Recurrence
Hepatitis D
Virus Diseases
Hepatitis B
Graft Survival
Virus Replication
Transplantation
Transplants
Hepatitis B e Antigens
Hepatitis B Surface Antigens

ASJC Scopus subject areas

  • Hepatology

Cite this

Marsman, W. A., Wiesner, R. H., Batts, K. P., Poterucha, J. J., Porayko, M. K., Niesters, H. G. M., ... Krom, R. A. F. (1997). Fulminant hepatitis B virus: Recurrence after liver transplantation in two patients also infected with hepatitis delta virus. Hepatology, 25(2), 434-438.

Fulminant hepatitis B virus : Recurrence after liver transplantation in two patients also infected with hepatitis delta virus. / Marsman, Willem A.; Wiesner, Russell H.; Batts, Kenneth P.; Poterucha, John J.; Porayko, Michael K.; Niesters, H. G M; Zondervan, Pieter E.; Krom, R. A F.

In: Hepatology, Vol. 25, No. 2, 02.1997, p. 434-438.

Research output: Contribution to journalArticle

Marsman, WA, Wiesner, RH, Batts, KP, Poterucha, JJ, Porayko, MK, Niesters, HGM, Zondervan, PE & Krom, RAF 1997, 'Fulminant hepatitis B virus: Recurrence after liver transplantation in two patients also infected with hepatitis delta virus', Hepatology, vol. 25, no. 2, pp. 434-438.
Marsman WA, Wiesner RH, Batts KP, Poterucha JJ, Porayko MK, Niesters HGM et al. Fulminant hepatitis B virus: Recurrence after liver transplantation in two patients also infected with hepatitis delta virus. Hepatology. 1997 Feb;25(2):434-438.
Marsman, Willem A. ; Wiesner, Russell H. ; Batts, Kenneth P. ; Poterucha, John J. ; Porayko, Michael K. ; Niesters, H. G M ; Zondervan, Pieter E. ; Krom, R. A F. / Fulminant hepatitis B virus : Recurrence after liver transplantation in two patients also infected with hepatitis delta virus. In: Hepatology. 1997 ; Vol. 25, No. 2. pp. 434-438.
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