Fukuoka criteria accurately predict risk for adverse outcomes during follow-up of pancreatic cysts presumed to be intraductal papillary mucinous neoplasms

Saurabh Mukewar, Nicolo de Pretis, Anupama Aryal-Khanal, Nazir Ahmed, Raghuwansh Sah, Felicity T Enders, Joseph J. Larson, Michael J. Levy, Naoki Takahashi, Mark Topazian, Randall Pearson, Santhi Swaroop Vege, Suresh T Chari

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Abstract

Objective Fukuoka consensus guidelines classify pancreatic cystic lesions (PCLs) presumed to be intraductal papillary mucinous neoplasms (IPMNs) into Fukuoka positive (FP) (subgroups of high-risk (HR) and worrisome features (WFs)) and Fukuoka negative (FN) (non-HR feature/WF cysts). We retrospectively estimated 5-year risk of pancreatic cancer (PC) in FN, WF and HR cysts of patients with PCL-IPMN. Design From Mayo Clinic databases, we randomly selected 2000 patients reported to have a PCL; we excluded inflammatory or suspected non-IPMN cysts and those without imaging follow-up. We re-reviewed crosssectional imaging and abstracted clinical and follow-up data on PCL-IPMNs. The study contained 802 patients with FN cysts and 358 with FP cysts. Results Patients with PCL-IPMN had median (IQR) follow-up of 4.2 (1.8-7.1) years. Among FN cysts, 5- year PC risk was low (2-3%) regardless of cyst size ( p=0.67). After excluding events in the first 6 months, 5-year PC risk remained low (0-2%) regardless of cyst size ( p=0.61). Among FP cysts, HR cysts (n=66) had greater 5-year PC risk than WF cysts (n=292) (49.7% vs 4.1%; p10 mm (79.8% vs 37.3% vs 39.4%, respectively; p=0.01). Conclusions Fukuoka guidelines accurately stratify PCL-IPMNs for PC risk, with FN cysts having lowest and HR cysts having greatest risk. After 6-month follow-up, WF and FN cysts had a low 5-year PC risk. Surveillance strategies should be tailored appropriately.

Original languageEnglish (US)
JournalGut
DOIs
StateAccepted/In press - Jul 7 2016

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ASJC Scopus subject areas

  • Gastroenterology

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Mukewar, S., de Pretis, N., Aryal-Khanal, A., Ahmed, N., Sah, R., Enders, F. T., Larson, J. J., Levy, M. J., Takahashi, N., Topazian, M., Pearson, R., Vege, S. S., & Chari, S. T. (Accepted/In press). Fukuoka criteria accurately predict risk for adverse outcomes during follow-up of pancreatic cysts presumed to be intraductal papillary mucinous neoplasms. Gut. https://doi.org/10.1136/gutjnl-2016-311615