FTD spectrum: Neuroimaging across the FTD spectrum

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Frontotemporal dementia is a complex and heterogeneous neurodegenerative disease that encompasses many clinical syndromes, pathological diseases, and genetic mutations. Neuroimaging has played a critical role in our understanding of the underlying pathophysiology of frontotemporal dementia and provided biomarkers to aid diagnosis. Early studies defined patterns of neurodegeneration and hypometabolism associated with the clinical, pathological and genetic aspects of frontotemporal dementia, with more recent studies highlighting how the breakdown of structural and functional brain networks define frontotemporal dementia. Molecular positron emission tomography ligands allowing the in vivo imaging of tau proteins have also provided important insights, although more work is needed to understand the biology of the currently available ligands.

Original languageEnglish (US)
Title of host publicationProgress in Molecular Biology and Translational Science
EditorsJames T. Becker, Ann D. Cohen
PublisherElsevier B.V.
Pages187-223
Number of pages37
ISBN (Print)9780128183618
DOIs
StatePublished - 2019

Publication series

NameProgress in Molecular Biology and Translational Science
Volume165
ISSN (Print)1877-1173
ISSN (Electronic)1878-0814

Keywords

  • Agrammatic
  • Apraxia of speech
  • Connectivity
  • MRI
  • Neurodegeneration
  • Progranulin, C9ORF72
  • Semantic
  • TDP-43
  • Tau

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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  • Cite this

    Whitwell, J. L. (2019). FTD spectrum: Neuroimaging across the FTD spectrum. In J. T. Becker, & A. D. Cohen (Eds.), Progress in Molecular Biology and Translational Science (pp. 187-223). (Progress in Molecular Biology and Translational Science; Vol. 165). Elsevier B.V.. https://doi.org/10.1016/bs.pmbts.2019.05.009