@inbook{e309208b2aa646f582acedfff699b279,
title = "FTD spectrum: Neuroimaging across the FTD spectrum",
abstract = "Frontotemporal dementia is a complex and heterogeneous neurodegenerative disease that encompasses many clinical syndromes, pathological diseases, and genetic mutations. Neuroimaging has played a critical role in our understanding of the underlying pathophysiology of frontotemporal dementia and provided biomarkers to aid diagnosis. Early studies defined patterns of neurodegeneration and hypometabolism associated with the clinical, pathological and genetic aspects of frontotemporal dementia, with more recent studies highlighting how the breakdown of structural and functional brain networks define frontotemporal dementia. Molecular positron emission tomography ligands allowing the in vivo imaging of tau proteins have also provided important insights, although more work is needed to understand the biology of the currently available ligands.",
keywords = "Agrammatic, Apraxia of speech, Connectivity, MRI, Neurodegeneration, Progranulin, C9ORF72, Semantic, TDP-43, Tau",
author = "Whitwell, {Jennifer L.}",
note = "Funding Information: Dr. Whitwell is funded by the National Institutes of Health (R01-DC12519, R01-AG50603, R01-NS89757, R21-NS94684 and R01-DC14942). Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
doi = "10.1016/bs.pmbts.2019.05.009",
language = "English (US)",
isbn = "9780128183618",
series = "Progress in Molecular Biology and Translational Science",
publisher = "Elsevier B.V.",
pages = "187--223",
editor = "Becker, {James T.} and Cohen, {Ann D.}",
booktitle = "Brain Imaging",
}