Frontotemporal dementia: A clinicopathological review of four postmortem studies

W. Michael Hooten, Constantine G. Lyketsos

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Frontotemporal dementia is a progressive dementing illness characterized clinically by personality change, disinhibition, and apathy. Neuropathologically, neuronal cell loss, astrogliosis, and microvacuolation are present in the superficial frontotemporal cortical layers, with variable involvement of subcortical and limbic structures. The clinical picture and anatomical distribution of the degenerative changes, as well as motor neuron involvement, differentiate four neuropathological groups: 1) frontal lobe type, 2) thalamostriatal type, 3) motor neuron type, and 4) asymmetrical type. The authors review the results of four large postmortem studies with a special emphasis on cliniconeuropathological correlation.

Original languageEnglish (US)
Pages (from-to)10-19
Number of pages10
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume8
Issue number1
StatePublished - 1996
Externally publishedYes

Fingerprint

Frontotemporal Dementia
Motor Neurons
Apathy
Frontal Lobe
Personality

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Frontotemporal dementia : A clinicopathological review of four postmortem studies. / Hooten, W. Michael; Lyketsos, Constantine G.

In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 8, No. 1, 1996, p. 10-19.

Research output: Contribution to journalArticle

@article{304757fe7c9b4a6e8577e933ddc2ba94,
title = "Frontotemporal dementia: A clinicopathological review of four postmortem studies",
abstract = "Frontotemporal dementia is a progressive dementing illness characterized clinically by personality change, disinhibition, and apathy. Neuropathologically, neuronal cell loss, astrogliosis, and microvacuolation are present in the superficial frontotemporal cortical layers, with variable involvement of subcortical and limbic structures. The clinical picture and anatomical distribution of the degenerative changes, as well as motor neuron involvement, differentiate four neuropathological groups: 1) frontal lobe type, 2) thalamostriatal type, 3) motor neuron type, and 4) asymmetrical type. The authors review the results of four large postmortem studies with a special emphasis on cliniconeuropathological correlation.",
author = "Hooten, {W. Michael} and Lyketsos, {Constantine G.}",
year = "1996",
language = "English (US)",
volume = "8",
pages = "10--19",
journal = "Journal of Neuropsychiatry and Clinical Neurosciences",
issn = "0895-0172",
publisher = "American Psychiatric Publishing Inc.",
number = "1",

}

TY - JOUR

T1 - Frontotemporal dementia

T2 - A clinicopathological review of four postmortem studies

AU - Hooten, W. Michael

AU - Lyketsos, Constantine G.

PY - 1996

Y1 - 1996

N2 - Frontotemporal dementia is a progressive dementing illness characterized clinically by personality change, disinhibition, and apathy. Neuropathologically, neuronal cell loss, astrogliosis, and microvacuolation are present in the superficial frontotemporal cortical layers, with variable involvement of subcortical and limbic structures. The clinical picture and anatomical distribution of the degenerative changes, as well as motor neuron involvement, differentiate four neuropathological groups: 1) frontal lobe type, 2) thalamostriatal type, 3) motor neuron type, and 4) asymmetrical type. The authors review the results of four large postmortem studies with a special emphasis on cliniconeuropathological correlation.

AB - Frontotemporal dementia is a progressive dementing illness characterized clinically by personality change, disinhibition, and apathy. Neuropathologically, neuronal cell loss, astrogliosis, and microvacuolation are present in the superficial frontotemporal cortical layers, with variable involvement of subcortical and limbic structures. The clinical picture and anatomical distribution of the degenerative changes, as well as motor neuron involvement, differentiate four neuropathological groups: 1) frontal lobe type, 2) thalamostriatal type, 3) motor neuron type, and 4) asymmetrical type. The authors review the results of four large postmortem studies with a special emphasis on cliniconeuropathological correlation.

UR - http://www.scopus.com/inward/record.url?scp=0030038866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030038866&partnerID=8YFLogxK

M3 - Article

C2 - 8845692

AN - SCOPUS:0030038866

VL - 8

SP - 10

EP - 19

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 1

ER -