From the archives of the AFIP. Imaging of osteochondroma

Variants and complications with radiologic-pathologic correlation

Mark D. Murphey, James J. Choi, Mark J. Kransdorf, Donald J. Flemming, Frances H. Gannon

Research output: Contribution to journalArticle

376 Citations (Scopus)

Abstract

Osteochondroma represents the most common bone tumor and is a developmental lesion rather than a true neoplasm. It constitutes 20%-50% of all benign bone tumors and 10%-15% of all bone tumors. Its radiologic features are often pathognomonic and identically reflect its pathologic appearance. Osteochondromas are composed of cortical and medullary bone with an overlying hyaline cartilage cap and must demonstrate continuity with the underlying parent bone cortex and medullary canal. Osteochondromas may be solitary or multiple, the latter being associated with the autosomal dominant syndrome, hereditary multiple exostoses (HME). Complications associated with osteochondromas are more frequent with HME and include deformity (cosmetic and osseous), fracture, vascular compromise, neurologic sequelae, overlying bursa formation, and malignant transformation. Malignant transformation is seen in 1% of solitary osteochondromas and in 3%-5% of patients with HME. Continued lesion growth and a hyaline cartilage cap greater than 1.5 cm in thickness, after skeletal maturity, suggest malignant transformation. Variants of osteochondroma include subungual exostosis, dysplasia epiphysealis hemimelica, turret and traction exostoses, bizarre parosteal osteochondromatous proliferation, and florid reactive periostitis. Recognition of the radiologic spectrum of appearances of osteochondroma and its variants usually allows prospective diagnosis and differentiation of the numerous potential complications, thus helping guide therapy and improving patient management.

Original languageEnglish (US)
Pages (from-to)1407-1434
Number of pages28
JournalRadiographics
Volume20
Issue number5
StatePublished - Sep 2000

Fingerprint

Osteochondroma
Multiple Hereditary Exostoses
Hyaline Cartilage
Bone and Bones
Neoplasms
Periostitis
Exostoses
Traction
Cosmetics
Nervous System
Blood Vessels
Growth

Keywords

  • Bone neoplasms, 40.3113, 40.1542
  • Osteochondroma, 40.3113, 40.1542
  • Osteochondromatosis, 40.365, 40.782

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Murphey, M. D., Choi, J. J., Kransdorf, M. J., Flemming, D. J., & Gannon, F. H. (2000). From the archives of the AFIP. Imaging of osteochondroma: Variants and complications with radiologic-pathologic correlation. Radiographics, 20(5), 1407-1434.

From the archives of the AFIP. Imaging of osteochondroma : Variants and complications with radiologic-pathologic correlation. / Murphey, Mark D.; Choi, James J.; Kransdorf, Mark J.; Flemming, Donald J.; Gannon, Frances H.

In: Radiographics, Vol. 20, No. 5, 09.2000, p. 1407-1434.

Research output: Contribution to journalArticle

Murphey, MD, Choi, JJ, Kransdorf, MJ, Flemming, DJ & Gannon, FH 2000, 'From the archives of the AFIP. Imaging of osteochondroma: Variants and complications with radiologic-pathologic correlation', Radiographics, vol. 20, no. 5, pp. 1407-1434.
Murphey, Mark D. ; Choi, James J. ; Kransdorf, Mark J. ; Flemming, Donald J. ; Gannon, Frances H. / From the archives of the AFIP. Imaging of osteochondroma : Variants and complications with radiologic-pathologic correlation. In: Radiographics. 2000 ; Vol. 20, No. 5. pp. 1407-1434.
@article{d7d64ab08c4f4b1f8febed4af7bfcee3,
title = "From the archives of the AFIP. Imaging of osteochondroma: Variants and complications with radiologic-pathologic correlation",
abstract = "Osteochondroma represents the most common bone tumor and is a developmental lesion rather than a true neoplasm. It constitutes 20{\%}-50{\%} of all benign bone tumors and 10{\%}-15{\%} of all bone tumors. Its radiologic features are often pathognomonic and identically reflect its pathologic appearance. Osteochondromas are composed of cortical and medullary bone with an overlying hyaline cartilage cap and must demonstrate continuity with the underlying parent bone cortex and medullary canal. Osteochondromas may be solitary or multiple, the latter being associated with the autosomal dominant syndrome, hereditary multiple exostoses (HME). Complications associated with osteochondromas are more frequent with HME and include deformity (cosmetic and osseous), fracture, vascular compromise, neurologic sequelae, overlying bursa formation, and malignant transformation. Malignant transformation is seen in 1{\%} of solitary osteochondromas and in 3{\%}-5{\%} of patients with HME. Continued lesion growth and a hyaline cartilage cap greater than 1.5 cm in thickness, after skeletal maturity, suggest malignant transformation. Variants of osteochondroma include subungual exostosis, dysplasia epiphysealis hemimelica, turret and traction exostoses, bizarre parosteal osteochondromatous proliferation, and florid reactive periostitis. Recognition of the radiologic spectrum of appearances of osteochondroma and its variants usually allows prospective diagnosis and differentiation of the numerous potential complications, thus helping guide therapy and improving patient management.",
keywords = "Bone neoplasms, 40.3113, 40.1542, Osteochondroma, 40.3113, 40.1542, Osteochondromatosis, 40.365, 40.782",
author = "Murphey, {Mark D.} and Choi, {James J.} and Kransdorf, {Mark J.} and Flemming, {Donald J.} and Gannon, {Frances H.}",
year = "2000",
month = "9",
language = "English (US)",
volume = "20",
pages = "1407--1434",
journal = "Radiographics",
issn = "0271-5333",
publisher = "Radiological Society of North America Inc.",
number = "5",

}

TY - JOUR

T1 - From the archives of the AFIP. Imaging of osteochondroma

T2 - Variants and complications with radiologic-pathologic correlation

AU - Murphey, Mark D.

AU - Choi, James J.

AU - Kransdorf, Mark J.

AU - Flemming, Donald J.

AU - Gannon, Frances H.

PY - 2000/9

Y1 - 2000/9

N2 - Osteochondroma represents the most common bone tumor and is a developmental lesion rather than a true neoplasm. It constitutes 20%-50% of all benign bone tumors and 10%-15% of all bone tumors. Its radiologic features are often pathognomonic and identically reflect its pathologic appearance. Osteochondromas are composed of cortical and medullary bone with an overlying hyaline cartilage cap and must demonstrate continuity with the underlying parent bone cortex and medullary canal. Osteochondromas may be solitary or multiple, the latter being associated with the autosomal dominant syndrome, hereditary multiple exostoses (HME). Complications associated with osteochondromas are more frequent with HME and include deformity (cosmetic and osseous), fracture, vascular compromise, neurologic sequelae, overlying bursa formation, and malignant transformation. Malignant transformation is seen in 1% of solitary osteochondromas and in 3%-5% of patients with HME. Continued lesion growth and a hyaline cartilage cap greater than 1.5 cm in thickness, after skeletal maturity, suggest malignant transformation. Variants of osteochondroma include subungual exostosis, dysplasia epiphysealis hemimelica, turret and traction exostoses, bizarre parosteal osteochondromatous proliferation, and florid reactive periostitis. Recognition of the radiologic spectrum of appearances of osteochondroma and its variants usually allows prospective diagnosis and differentiation of the numerous potential complications, thus helping guide therapy and improving patient management.

AB - Osteochondroma represents the most common bone tumor and is a developmental lesion rather than a true neoplasm. It constitutes 20%-50% of all benign bone tumors and 10%-15% of all bone tumors. Its radiologic features are often pathognomonic and identically reflect its pathologic appearance. Osteochondromas are composed of cortical and medullary bone with an overlying hyaline cartilage cap and must demonstrate continuity with the underlying parent bone cortex and medullary canal. Osteochondromas may be solitary or multiple, the latter being associated with the autosomal dominant syndrome, hereditary multiple exostoses (HME). Complications associated with osteochondromas are more frequent with HME and include deformity (cosmetic and osseous), fracture, vascular compromise, neurologic sequelae, overlying bursa formation, and malignant transformation. Malignant transformation is seen in 1% of solitary osteochondromas and in 3%-5% of patients with HME. Continued lesion growth and a hyaline cartilage cap greater than 1.5 cm in thickness, after skeletal maturity, suggest malignant transformation. Variants of osteochondroma include subungual exostosis, dysplasia epiphysealis hemimelica, turret and traction exostoses, bizarre parosteal osteochondromatous proliferation, and florid reactive periostitis. Recognition of the radiologic spectrum of appearances of osteochondroma and its variants usually allows prospective diagnosis and differentiation of the numerous potential complications, thus helping guide therapy and improving patient management.

KW - Bone neoplasms, 40.3113, 40.1542

KW - Osteochondroma, 40.3113, 40.1542

KW - Osteochondromatosis, 40.365, 40.782

UR - http://www.scopus.com/inward/record.url?scp=0034263408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034263408&partnerID=8YFLogxK

M3 - Article

VL - 20

SP - 1407

EP - 1434

JO - Radiographics

JF - Radiographics

SN - 0271-5333

IS - 5

ER -