From the American Epilepsy Society 2009 Annual Course Non-substrate-directed epilepsy and surgery

PRO and CON

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The surgical treatment of epilepsy is the most efficacious therapeutic modality for patients with a medically refractory partial seizure disorder. Epilepsy surgery has been demonstrated to be both effective and well tolerated in individuals with medial temporal lobe epilepsy associated with mesial temporal sclerosis. The identification of an MRI pathological substrate may be useful in identifying the epileptogenic zone and the appropriate operative strategy, and is predictive of the long-term seizure outcome. Patients with a non-substrate-directed partial epilepsy often require a more rigorous presurgical evaluation because of issues regarding the lateralization and localization of the epileptic brain tissue. The surgical outcome may be most disappointing in individuals with localization-related epilepsy of extratemporal origin associated with a normal MRI study. The present discussion focuses on the selection of patients with extratemporal non-substrate-directed epilepsy for a presurgical evaluation. The important factors associated with an improved quality of life subsequent to epilepsy surgery include seizure remission and avoidance of operation-induced adverse effects.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalEpilepsy and Behavior
Volume20
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Partial Epilepsy
Epilepsy
Seizures
Temporal Lobe Epilepsy
Sclerosis
Patient Selection
Quality of Life
Brain
Therapeutics

Keywords

  • Frontal lobe epilepsy
  • Intracranial electroencephalography
  • Lesional epilepsy
  • Surgery
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

Cite this

@article{c146041b066e4758aeec5985161e74fe,
title = "From the American Epilepsy Society 2009 Annual Course Non-substrate-directed epilepsy and surgery: PRO and CON",
abstract = "The surgical treatment of epilepsy is the most efficacious therapeutic modality for patients with a medically refractory partial seizure disorder. Epilepsy surgery has been demonstrated to be both effective and well tolerated in individuals with medial temporal lobe epilepsy associated with mesial temporal sclerosis. The identification of an MRI pathological substrate may be useful in identifying the epileptogenic zone and the appropriate operative strategy, and is predictive of the long-term seizure outcome. Patients with a non-substrate-directed partial epilepsy often require a more rigorous presurgical evaluation because of issues regarding the lateralization and localization of the epileptic brain tissue. The surgical outcome may be most disappointing in individuals with localization-related epilepsy of extratemporal origin associated with a normal MRI study. The present discussion focuses on the selection of patients with extratemporal non-substrate-directed epilepsy for a presurgical evaluation. The important factors associated with an improved quality of life subsequent to epilepsy surgery include seizure remission and avoidance of operation-induced adverse effects.",
keywords = "Frontal lobe epilepsy, Intracranial electroencephalography, Lesional epilepsy, Surgery, Temporal lobe epilepsy",
author = "Cascino, {Gregory D}",
year = "2011",
month = "2",
doi = "10.1016/j.yebeh.2010.12.014",
language = "English (US)",
volume = "20",
pages = "190--193",
journal = "Epilepsy and Behavior",
issn = "1525-5050",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - From the American Epilepsy Society 2009 Annual Course Non-substrate-directed epilepsy and surgery

T2 - PRO and CON

AU - Cascino, Gregory D

PY - 2011/2

Y1 - 2011/2

N2 - The surgical treatment of epilepsy is the most efficacious therapeutic modality for patients with a medically refractory partial seizure disorder. Epilepsy surgery has been demonstrated to be both effective and well tolerated in individuals with medial temporal lobe epilepsy associated with mesial temporal sclerosis. The identification of an MRI pathological substrate may be useful in identifying the epileptogenic zone and the appropriate operative strategy, and is predictive of the long-term seizure outcome. Patients with a non-substrate-directed partial epilepsy often require a more rigorous presurgical evaluation because of issues regarding the lateralization and localization of the epileptic brain tissue. The surgical outcome may be most disappointing in individuals with localization-related epilepsy of extratemporal origin associated with a normal MRI study. The present discussion focuses on the selection of patients with extratemporal non-substrate-directed epilepsy for a presurgical evaluation. The important factors associated with an improved quality of life subsequent to epilepsy surgery include seizure remission and avoidance of operation-induced adverse effects.

AB - The surgical treatment of epilepsy is the most efficacious therapeutic modality for patients with a medically refractory partial seizure disorder. Epilepsy surgery has been demonstrated to be both effective and well tolerated in individuals with medial temporal lobe epilepsy associated with mesial temporal sclerosis. The identification of an MRI pathological substrate may be useful in identifying the epileptogenic zone and the appropriate operative strategy, and is predictive of the long-term seizure outcome. Patients with a non-substrate-directed partial epilepsy often require a more rigorous presurgical evaluation because of issues regarding the lateralization and localization of the epileptic brain tissue. The surgical outcome may be most disappointing in individuals with localization-related epilepsy of extratemporal origin associated with a normal MRI study. The present discussion focuses on the selection of patients with extratemporal non-substrate-directed epilepsy for a presurgical evaluation. The important factors associated with an improved quality of life subsequent to epilepsy surgery include seizure remission and avoidance of operation-induced adverse effects.

KW - Frontal lobe epilepsy

KW - Intracranial electroencephalography

KW - Lesional epilepsy

KW - Surgery

KW - Temporal lobe epilepsy

UR - http://www.scopus.com/inward/record.url?scp=79951669776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951669776&partnerID=8YFLogxK

U2 - 10.1016/j.yebeh.2010.12.014

DO - 10.1016/j.yebeh.2010.12.014

M3 - Article

VL - 20

SP - 190

EP - 193

JO - Epilepsy and Behavior

JF - Epilepsy and Behavior

SN - 1525-5050

IS - 2

ER -