From cloning to structure, function, and regulation of chloride-dependent and independent bicarbonate transporters

Michael F. Romero; Min Hwang Chang; David B. Mount

doi:10.1016/B978-0-12-374373-2.00004-2

From cloning to structure, function, and regulation of chloride-dependent and independent bicarbonate transporters

Michael F. Romero, Min Hwang Chang, David B. Mount

Physiology & Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Chapter

3 Scopus citations

Abstract

This chapter deals with regulation of chloride-dependent and independent bicarbonate transporters. Regulation of acid-base homeostasis as well as other ionic concentrations, such as Na⁺, is critical for animal life. Vertebrates, mammals in particular, generate significant amounts of acid via metabolism; these organisms must excrete acid (H⁺) or increase systemic HCO₃ concentration to buffer this metabolic acid. Bicarbonate, along with CO₂, is the major pH buffering system of biological fluids. The chapter also defines the modes of membrane anion transport. Membranes present a barrier to the movement of ions and other solutes. The cell membrane is a mosaic of phospholipids, cholesterol and proteins. The phospholipids make the bulk of the membrane and form a bilayer. This lipid bilayer has the hydrophilic phosphate and sugar head-groups facing both the outside world and the inside world.

Original language	English (US)
Title of host publication	Physiology and Pathology of chloride transporters and channels in the nervous system
Publisher	Elsevier Inc.
Pages	43-79
Number of pages	37
ISBN (Print)	9780123743732
DOIs	https://doi.org/10.1016/B978-0-12-374373-2.00004-2
State	Published - 2010

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/B978-0-12-374373-2.00004-2

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title = "From cloning to structure, function, and regulation of chloride-dependent and independent bicarbonate transporters",

abstract = "This chapter deals with regulation of chloride-dependent and independent bicarbonate transporters. Regulation of acid-base homeostasis as well as other ionic concentrations, such as Na+, is critical for animal life. Vertebrates, mammals in particular, generate significant amounts of acid via metabolism; these organisms must excrete acid (H+) or increase systemic HCO3 concentration to buffer this metabolic acid. Bicarbonate, along with CO2, is the major pH buffering system of biological fluids. The chapter also defines the modes of membrane anion transport. Membranes present a barrier to the movement of ions and other solutes. The cell membrane is a mosaic of phospholipids, cholesterol and proteins. The phospholipids make the bulk of the membrane and form a bilayer. This lipid bilayer has the hydrophilic phosphate and sugar head-groups facing both the outside world and the inside world.",

author = "Romero, {Michael F.} and Chang, {Min Hwang} and Mount, {David B.}",

note = "Funding Information: We thank the members of the Romero and Mount laboratories for excellent technical support as well as help with this work: N. Angle, G. Babcock, H. Holmes, C. Plata, E. Scileppi, A. Sindic, L. Song, Q. Xie, R. Welch and M. Sanders. This work was supported by NIH grants DK056218, DK060845, EY017732 (MFR); DK038226, DK070756, DK57708 (DBM). Other funding includes an Advanced Career Development Award from the Veterans Administration (DBM); postdoctoral fellowship from AHA (M-HC); and the Cystic Fibrosis Foundation (ROMERO-06G0). ",

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AU - Romero, Michael F.

AU - Chang, Min Hwang

AU - Mount, David B.

N1 - Funding Information: We thank the members of the Romero and Mount laboratories for excellent technical support as well as help with this work: N. Angle, G. Babcock, H. Holmes, C. Plata, E. Scileppi, A. Sindic, L. Song, Q. Xie, R. Welch and M. Sanders. This work was supported by NIH grants DK056218, DK060845, EY017732 (MFR); DK038226, DK070756, DK57708 (DBM). Other funding includes an Advanced Career Development Award from the Veterans Administration (DBM); postdoctoral fellowship from AHA (M-HC); and the Cystic Fibrosis Foundation (ROMERO-06G0).

PY - 2010

Y1 - 2010

N2 - This chapter deals with regulation of chloride-dependent and independent bicarbonate transporters. Regulation of acid-base homeostasis as well as other ionic concentrations, such as Na+, is critical for animal life. Vertebrates, mammals in particular, generate significant amounts of acid via metabolism; these organisms must excrete acid (H+) or increase systemic HCO3 concentration to buffer this metabolic acid. Bicarbonate, along with CO2, is the major pH buffering system of biological fluids. The chapter also defines the modes of membrane anion transport. Membranes present a barrier to the movement of ions and other solutes. The cell membrane is a mosaic of phospholipids, cholesterol and proteins. The phospholipids make the bulk of the membrane and form a bilayer. This lipid bilayer has the hydrophilic phosphate and sugar head-groups facing both the outside world and the inside world.

AB - This chapter deals with regulation of chloride-dependent and independent bicarbonate transporters. Regulation of acid-base homeostasis as well as other ionic concentrations, such as Na+, is critical for animal life. Vertebrates, mammals in particular, generate significant amounts of acid via metabolism; these organisms must excrete acid (H+) or increase systemic HCO3 concentration to buffer this metabolic acid. Bicarbonate, along with CO2, is the major pH buffering system of biological fluids. The chapter also defines the modes of membrane anion transport. Membranes present a barrier to the movement of ions and other solutes. The cell membrane is a mosaic of phospholipids, cholesterol and proteins. The phospholipids make the bulk of the membrane and form a bilayer. This lipid bilayer has the hydrophilic phosphate and sugar head-groups facing both the outside world and the inside world.

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BT - Physiology and Pathology of chloride transporters and channels in the nervous system

PB - Elsevier Inc.

ER -

From cloning to structure, function, and regulation of chloride-dependent and independent bicarbonate transporters

Abstract

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