FREQUENCY OF SEVERE NEUTROPENIA ASSOCIATED WITH AMODIAQUINE PROPHYLAXIS AGAINST MALARIA

C. S.R. Hatton, C. Bunch, T. E.A. Peto, G. Pasvol, S. J. Russell, C. R.J. Singer, G. Edwards, P. Winstanley

Research output: Contribution to journalArticlepeer-review

184 Scopus citations

Abstract

6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken co-trimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.

Original languageEnglish (US)
Pages (from-to)411-414
Number of pages4
JournalThe Lancet
Volume327
Issue number8478
DOIs
StatePublished - Feb 22 1986

ASJC Scopus subject areas

  • Medicine(all)

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