FREQUENCY OF SEVERE NEUTROPENIA ASSOCIATED WITH AMODIAQUINE PROPHYLAXIS AGAINST MALARIA

C. S R Hatton, C. Bunch, T. E A Peto, G. Pasvol, Stephen J Russell, C. R J Singer, G. Edwards, P. Winstanley

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182 Scopus citations

Abstract

6 out of 7 patients with severe neutropenia associated with the use of amodiaquine for malaria prophylaxis amodiaquine (400 mg weekly) plus proguanil (200 mg daily); 1 of these patients had also taken co-trimoxazole and another had taken sulphaguanidine. The 7th patient had taken amodiaquine alone, but at a higher dose. A retrospective analysis suggests that the frequency of severe neutropenia complicating amodiaquine taken prophylactically may be as high as 1 in 2000.

Original languageEnglish (US)
Pages (from-to)411-414
Number of pages4
JournalThe Lancet
Volume327
Issue number8478
DOIs
StatePublished - Feb 22 1986
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Hatton, C. S. R., Bunch, C., Peto, T. E. A., Pasvol, G., Russell, S. J., Singer, C. R. J., Edwards, G., & Winstanley, P. (1986). FREQUENCY OF SEVERE NEUTROPENIA ASSOCIATED WITH AMODIAQUINE PROPHYLAXIS AGAINST MALARIA. The Lancet, 327(8478), 411-414. https://doi.org/10.1016/S0140-6736(86)92371-8