Abstract
Among 10 patients with amyotrophic lateral sclerosis who had combined biopsy of muscle and cutaneous nerves, two had a history of paresthesia that suggested involvement of peripheral afferent neurons. Of four patients without paresthesia, two had unequivocal abnormalities of touch pressure sensation of the toe. On morphometric evaluations of lateral fascicles of deep peroneal nerve, one nerve had an abnormally low myelinated fiber density and seven of 10 had abnormally high frequencies of teased fiber abnormalities. Teased fibers in which myelin was degenerating into linear rows of myelin ovoids and balls occurred in 10.5 percent of fibers in amyotrophic lateral sclerosis nerves as compared with 1.7 percent in control nerves (0.01<p<0.025). Estimates of density of myelinated fibers were less sensitive than estimates of the frequency of various changes in teased fibers for detecting abnormality.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 781-785 |
| Number of pages | 5 |
| Journal | Neurology |
| Volume | 25 |
| Issue number | 8 |
| State | Published - 1975 |
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ASJC Scopus subject areas
- Neuroscience(all)
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Frequency of nerve fiber degeneration of peripheral motor and sensory neurons in amyotrophic lateral sclerosis. Morphometry of deep and superficial peroneal nerves. / Dyck, Peter J; Stevens, J. C.; Mulder, D. W.; Espinosa, Raul Emilio.
In: Neurology, Vol. 25, No. 8, 1975, p. 781-785.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frequency of nerve fiber degeneration of peripheral motor and sensory neurons in amyotrophic lateral sclerosis. Morphometry of deep and superficial peroneal nerves
AU - Dyck, Peter J
AU - Stevens, J. C.
AU - Mulder, D. W.
AU - Espinosa, Raul Emilio
PY - 1975
Y1 - 1975
N2 - Among 10 patients with amyotrophic lateral sclerosis who had combined biopsy of muscle and cutaneous nerves, two had a history of paresthesia that suggested involvement of peripheral afferent neurons. Of four patients without paresthesia, two had unequivocal abnormalities of touch pressure sensation of the toe. On morphometric evaluations of lateral fascicles of deep peroneal nerve, one nerve had an abnormally low myelinated fiber density and seven of 10 had abnormally high frequencies of teased fiber abnormalities. Teased fibers in which myelin was degenerating into linear rows of myelin ovoids and balls occurred in 10.5 percent of fibers in amyotrophic lateral sclerosis nerves as compared with 1.7 percent in control nerves (0.01
AB - Among 10 patients with amyotrophic lateral sclerosis who had combined biopsy of muscle and cutaneous nerves, two had a history of paresthesia that suggested involvement of peripheral afferent neurons. Of four patients without paresthesia, two had unequivocal abnormalities of touch pressure sensation of the toe. On morphometric evaluations of lateral fascicles of deep peroneal nerve, one nerve had an abnormally low myelinated fiber density and seven of 10 had abnormally high frequencies of teased fiber abnormalities. Teased fibers in which myelin was degenerating into linear rows of myelin ovoids and balls occurred in 10.5 percent of fibers in amyotrophic lateral sclerosis nerves as compared with 1.7 percent in control nerves (0.01
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UR - http://www.scopus.com/inward/citedby.url?scp=0016788436&partnerID=8YFLogxK
M3 - Article
C2 - 1171412
AN - SCOPUS:0016788436
VL - 25
SP - 781
EP - 785
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 8
ER -