Frequency of adverse reactions to influenza vaccine in the elderly. A randomized, placebo-controlled trial

K. L. Margolis, K. L. Nichol, G. A. Poland, R. E. Pluhar

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

Concern about side effects constitutes a major deterrent to patient compliance with influenza vaccination, yet there is a paucity of data about the occurrence of adverse reactions in the population targeted for immunization. We conducted a randomized, double-blind, crossover trial to compare the frequency of adverse reactions following administration of 1988-1989 trivalent split-antigen influenza vaccine and saline placebo. Outpatient veterans 65 years of age or over (n = 336) were recruited by mail and were randomly assigned to receive vaccine followed 2 weeks later by placebo injection or placebo followed 2 weeks later by vaccine. There was no significant difference between influenza vaccine and placebo with respect to the proportion of subjects reporting disability or systemic symptoms.

Original languageEnglish (US)
Pages (from-to)1139-1141
Number of pages3
JournalJournal of the American Medical Association
Volume264
Issue number9
DOIs
StatePublished - 1990

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Influenza Vaccines
Randomized Controlled Trials
Placebos
Vaccines
Postal Service
Veterans
Patient Compliance
Cross-Over Studies
Human Influenza
Immunization
Vaccination
Outpatients
Antigens
Injections
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Frequency of adverse reactions to influenza vaccine in the elderly. A randomized, placebo-controlled trial. / Margolis, K. L.; Nichol, K. L.; Poland, G. A.; Pluhar, R. E.

In: Journal of the American Medical Association, Vol. 264, No. 9, 1990, p. 1139-1141.

Research output: Contribution to journalArticle

Margolis, K. L. ; Nichol, K. L. ; Poland, G. A. ; Pluhar, R. E. / Frequency of adverse reactions to influenza vaccine in the elderly. A randomized, placebo-controlled trial. In: Journal of the American Medical Association. 1990 ; Vol. 264, No. 9. pp. 1139-1141.
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