Frequency of Acute and Subacute Infarcts in a Population-Based Study

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Abstract

Objective: To determine the frequency of incidental acute or subacute cerebral infarction (CI) in a population-based study. Patients and Methods: We identified 2095 participants aged 50 to 98 years in the population-based Mayo Clinic Study of Aging from October 23, 2009, to October 5, 2016, with a usable diffusion tensor imaging (DTI) sequence (total scans=3230). Acute and subacute infarcts were identified by neuroradiologists. For each participant, vascular risk factors, medications, clinical symptoms, and neurological examination near the time of the CI were abstracted from the medical record. The probable etiologic mechanism for the CI was determined. Results: Nine CIs were identified with a frequency of 0.28% among individual magnetic resonance imaging (MRI) scans and 0.43% among unique individuals. Infarctions were detected in 0.097% of scans from participants younger than 70 years and in 0.36% of scans of those 70 years or older. Six CIs were acute, and 3 were subacute. Most participants with infarcts were men (78%), with a mean age of 76.9±6.74 years. All were asymptomatic at the time of CI detection. The probable mechanisms of CI were small vessel (n=6), cardioembolic (n=2), and cryptogenic (n=1). Conclusion: Acute and subacute cerebral infarcts occur as incidental findings in approximately 1 in 230 people aged 50 to 98 years, particularly in elderly men and those with vascular risk factors. As brain MRI becomes more widely used, incidentally detected acute or subacute infarcts will provide an opportunity to improve stroke prevention.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalMayo Clinic Proceedings
Volume93
Issue number3
DOIs
StatePublished - Mar 1 2018

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Cerebral Infarction
Population
Magnetic Resonance Imaging
Diffusion Tensor Imaging
Incidental Findings
Neurologic Examination
Infarction
Medical Records
Stroke
Brain
vascular factor

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{0ddd7c2f1e1d4a1eb13f1eb8f238a1e2,
title = "Frequency of Acute and Subacute Infarcts in a Population-Based Study",
abstract = "Objective: To determine the frequency of incidental acute or subacute cerebral infarction (CI) in a population-based study. Patients and Methods: We identified 2095 participants aged 50 to 98 years in the population-based Mayo Clinic Study of Aging from October 23, 2009, to October 5, 2016, with a usable diffusion tensor imaging (DTI) sequence (total scans=3230). Acute and subacute infarcts were identified by neuroradiologists. For each participant, vascular risk factors, medications, clinical symptoms, and neurological examination near the time of the CI were abstracted from the medical record. The probable etiologic mechanism for the CI was determined. Results: Nine CIs were identified with a frequency of 0.28{\%} among individual magnetic resonance imaging (MRI) scans and 0.43{\%} among unique individuals. Infarctions were detected in 0.097{\%} of scans from participants younger than 70 years and in 0.36{\%} of scans of those 70 years or older. Six CIs were acute, and 3 were subacute. Most participants with infarcts were men (78{\%}), with a mean age of 76.9±6.74 years. All were asymptomatic at the time of CI detection. The probable mechanisms of CI were small vessel (n=6), cardioembolic (n=2), and cryptogenic (n=1). Conclusion: Acute and subacute cerebral infarcts occur as incidental findings in approximately 1 in 230 people aged 50 to 98 years, particularly in elderly men and those with vascular risk factors. As brain MRI becomes more widely used, incidentally detected acute or subacute infarcts will provide an opportunity to improve stroke prevention.",
author = "{Arnold Fiebelkorn}, Catherine and Vemuri, {Prashanthi D} and Alejandro Rabinstein and Mielke, {Michelle M} and Przybelski, {Scott A.} and Kantarci, {Kejal M} and Jones, {David T} and Brown, {Robert D Jr.} and Knopman, {David S} and Petersen, {Ronald Carl} and Jack, {Clifford R Jr.} and Jonathan Graff-Radford",
year = "2018",
month = "3",
day = "1",
doi = "10.1016/j.mayocp.2017.11.021",
language = "English (US)",
volume = "93",
pages = "300--306",
journal = "Mayo Clinic Proceedings",
issn = "0025-6196",
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TY - JOUR

T1 - Frequency of Acute and Subacute Infarcts in a Population-Based Study

AU - Arnold Fiebelkorn, Catherine

AU - Vemuri, Prashanthi D

AU - Rabinstein, Alejandro

AU - Mielke, Michelle M

AU - Przybelski, Scott A.

AU - Kantarci, Kejal M

AU - Jones, David T

AU - Brown, Robert D Jr.

AU - Knopman, David S

AU - Petersen, Ronald Carl

AU - Jack, Clifford R Jr.

AU - Graff-Radford, Jonathan

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Objective: To determine the frequency of incidental acute or subacute cerebral infarction (CI) in a population-based study. Patients and Methods: We identified 2095 participants aged 50 to 98 years in the population-based Mayo Clinic Study of Aging from October 23, 2009, to October 5, 2016, with a usable diffusion tensor imaging (DTI) sequence (total scans=3230). Acute and subacute infarcts were identified by neuroradiologists. For each participant, vascular risk factors, medications, clinical symptoms, and neurological examination near the time of the CI were abstracted from the medical record. The probable etiologic mechanism for the CI was determined. Results: Nine CIs were identified with a frequency of 0.28% among individual magnetic resonance imaging (MRI) scans and 0.43% among unique individuals. Infarctions were detected in 0.097% of scans from participants younger than 70 years and in 0.36% of scans of those 70 years or older. Six CIs were acute, and 3 were subacute. Most participants with infarcts were men (78%), with a mean age of 76.9±6.74 years. All were asymptomatic at the time of CI detection. The probable mechanisms of CI were small vessel (n=6), cardioembolic (n=2), and cryptogenic (n=1). Conclusion: Acute and subacute cerebral infarcts occur as incidental findings in approximately 1 in 230 people aged 50 to 98 years, particularly in elderly men and those with vascular risk factors. As brain MRI becomes more widely used, incidentally detected acute or subacute infarcts will provide an opportunity to improve stroke prevention.

AB - Objective: To determine the frequency of incidental acute or subacute cerebral infarction (CI) in a population-based study. Patients and Methods: We identified 2095 participants aged 50 to 98 years in the population-based Mayo Clinic Study of Aging from October 23, 2009, to October 5, 2016, with a usable diffusion tensor imaging (DTI) sequence (total scans=3230). Acute and subacute infarcts were identified by neuroradiologists. For each participant, vascular risk factors, medications, clinical symptoms, and neurological examination near the time of the CI were abstracted from the medical record. The probable etiologic mechanism for the CI was determined. Results: Nine CIs were identified with a frequency of 0.28% among individual magnetic resonance imaging (MRI) scans and 0.43% among unique individuals. Infarctions were detected in 0.097% of scans from participants younger than 70 years and in 0.36% of scans of those 70 years or older. Six CIs were acute, and 3 were subacute. Most participants with infarcts were men (78%), with a mean age of 76.9±6.74 years. All were asymptomatic at the time of CI detection. The probable mechanisms of CI were small vessel (n=6), cardioembolic (n=2), and cryptogenic (n=1). Conclusion: Acute and subacute cerebral infarcts occur as incidental findings in approximately 1 in 230 people aged 50 to 98 years, particularly in elderly men and those with vascular risk factors. As brain MRI becomes more widely used, incidentally detected acute or subacute infarcts will provide an opportunity to improve stroke prevention.

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U2 - 10.1016/j.mayocp.2017.11.021

DO - 10.1016/j.mayocp.2017.11.021

M3 - Article

C2 - 29426582

AN - SCOPUS:85042303599

VL - 93

SP - 300

EP - 306

JO - Mayo Clinic Proceedings

JF - Mayo Clinic Proceedings

SN - 0025-6196

IS - 3

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