Frequency-dependent functional neuromodulatory effects on the motor network by ventral lateral thalamic deep brain stimulation in swine

Seungleal B. Paek, Hoon Ki Min, Inyong Kim, Emily J. Knight, James J. Baek, Allan J. Bieber, Kendall H. Lee, Su Youne Chang

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Thalamic deep brain stimulation (DBS) is an FDA-approved neurosurgical treatment for medication-refractory essential tremor. Its therapeutic benefit is highly dependent upon stimulation frequency and voltage parameters. We investigated these stimulation parameter-dependent effects on neural network activation by performing functional magnetic resonance imaging (fMRI) during DBS of the ventral lateral (VL) thalamus and comparing the blood oxygenation level-dependent (BOLD) signals induced by multiple stimulation parameter combinations in a within-subject study of swine. Low (10. Hz) and high (130. Hz) frequency stimulation was applied at 3, 5, and 7. V in the VL thalamus of normal swine (n. =. 5). We found that stimulation frequency and voltage combinations differentially modulated the brain network activity in the sensorimotor cortex, the basal ganglia, and the cerebellum in a parameter-dependent manner. Notably, in the motor cortex, high frequency stimulation generated a negative BOLD response, while low frequency stimulation increased the positive BOLD response. These frequency-dependent differential effects suggest that the VL thalamus is an exemplary target for investigating functional network connectivity associated with therapeutic DBS.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalNeuroImage
Volume105
DOIs
StatePublished - Jan 5 2015

Keywords

  • Deep brain stimulation (DBS)
  • Essential tremor (ET)
  • FMRI
  • High frequency stimulation (HFS)
  • Low frequency stimulation (LFS)
  • Ventral lateral thalamus (VL thalamus)

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

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