Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease

Ipek Gungor; Lidia Sarro; Jonathan Graff-Radford; Samantha M. Zuk; Nirubol Tosakulwong; Scott A. Przybelski; Tim Lesnick; Bradley F. Boeve; Tanis J. Ferman; Glenn E. Smith; David S. Knopman; Massimo Filippi; Ronald C. Petersen; Clifford R. Jack; Kejal Kantarci

doi:10.1016/j.parkreldis.2015.07.008

Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease

Ipek Gungor, Lidia Sarro, Jonathan Graff-Radford, Samantha M. Zuk, Nirubol Tosakulwong, Scott A. Przybelski, Tim Lesnick, Bradley F. Boeve, Tanis J. Ferman, Glenn E. Smith, David S. Knopman, Massimo Filippi, Ronald C. Petersen, Clifford R. Jack, Kejal Kantarci

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Aim: To determine the frequency and topographic distribution of cerebral microbleeds (CMBs) in dementia with Lewy bodies (DLB) in comparison to CMBs in Alzheimer disease dementia (AD). Methods: Consecutive probable DLB (n = 23) patients who underwent 3-T T2* weighted gradient-recalled-echo MRI, and age and gender matched probable Alzheimer's disease patients (n = 46) were compared for the frequency and location of CMBs. Results: The frequency of one or more CMBs was similar among patients with DLB (30%) and AD (24%). Highest densities of CMBs were found in the occipital lobes of patients with both DLB and AD. Patients with AD had greater densities of CMBs in the parietal, temporal lobes and infratentorial regions compared to DLB (p < 0.05). Conclusion: CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases.

Original language	English (US)
Pages (from-to)	1101-1104
Number of pages	4
Journal	Parkinsonism and Related Disorders
Volume	21
Issue number	9
DOIs	https://doi.org/10.1016/j.parkreldis.2015.07.008
State	Published - Sep 1 2015

Keywords

Alzheimer disease
Cerebral amyloid angiopathy
Cerebral microbleeds
Dementia with Lewy bodies
T2* weighted gradient-recalled-echo MRI

ASJC Scopus subject areas

Neurology
Geriatrics and Gerontology
Clinical Neurology

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10.1016/j.parkreldis.2015.07.008

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Gungor, I., Sarro, L., Graff-Radford, J., Zuk, S. M., Tosakulwong, N., Przybelski, S. A., Lesnick, T., Boeve, B. F., Ferman, T. J., Smith, G. E., Knopman, D. S., Filippi, M., Petersen, R. C., Jack, C. R., & Kantarci, K. (2015). Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease. Parkinsonism and Related Disorders, 21(9), 1101-1104. https://doi.org/10.1016/j.parkreldis.2015.07.008

Gungor, I, Sarro, L, Graff-Radford, J, Zuk, SM, Tosakulwong, N, Przybelski, SA, Lesnick, T, Boeve, BF , Ferman, TJ, Smith, GE, Knopman, DS, Filippi, M, Petersen, RC , Jack, CR & Kantarci, K 2015, 'Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease', Parkinsonism and Related Disorders, vol. 21, no. 9, pp. 1101-1104. https://doi.org/10.1016/j.parkreldis.2015.07.008

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abstract = "Aim: To determine the frequency and topographic distribution of cerebral microbleeds (CMBs) in dementia with Lewy bodies (DLB) in comparison to CMBs in Alzheimer disease dementia (AD). Methods: Consecutive probable DLB (n = 23) patients who underwent 3-T T2* weighted gradient-recalled-echo MRI, and age and gender matched probable Alzheimer's disease patients (n = 46) were compared for the frequency and location of CMBs. Results: The frequency of one or more CMBs was similar among patients with DLB (30%) and AD (24%). Highest densities of CMBs were found in the occipital lobes of patients with both DLB and AD. Patients with AD had greater densities of CMBs in the parietal, temporal lobes and infratentorial regions compared to DLB (p < 0.05). Conclusion: CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases.",

keywords = "Alzheimer disease, Cerebral amyloid angiopathy, Cerebral microbleeds, Dementia with Lewy bodies, T2* weighted gradient-recalled-echo MRI",

author = "Ipek Gungor and Lidia Sarro and Jonathan Graff-Radford and Zuk, {Samantha M.} and Nirubol Tosakulwong and Przybelski, {Scott A.} and Tim Lesnick and Boeve, {Bradley F.} and Ferman, {Tanis J.} and Smith, {Glenn E.} and Knopman, {David S.} and Massimo Filippi and Petersen, {Ronald C.} and Jack, {Clifford R.} and Kejal Kantarci",

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doi = "10.1016/j.parkreldis.2015.07.008",

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T1 - Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease

AU - Gungor, Ipek

AU - Sarro, Lidia

AU - Graff-Radford, Jonathan

AU - Zuk, Samantha M.

AU - Tosakulwong, Nirubol

AU - Przybelski, Scott A.

AU - Lesnick, Tim

AU - Boeve, Bradley F.

AU - Ferman, Tanis J.

AU - Smith, Glenn E.

AU - Knopman, David S.

AU - Filippi, Massimo

AU - Petersen, Ronald C.

AU - Jack, Clifford R.

AU - Kantarci, Kejal

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Aim: To determine the frequency and topographic distribution of cerebral microbleeds (CMBs) in dementia with Lewy bodies (DLB) in comparison to CMBs in Alzheimer disease dementia (AD). Methods: Consecutive probable DLB (n = 23) patients who underwent 3-T T2* weighted gradient-recalled-echo MRI, and age and gender matched probable Alzheimer's disease patients (n = 46) were compared for the frequency and location of CMBs. Results: The frequency of one or more CMBs was similar among patients with DLB (30%) and AD (24%). Highest densities of CMBs were found in the occipital lobes of patients with both DLB and AD. Patients with AD had greater densities of CMBs in the parietal, temporal lobes and infratentorial regions compared to DLB (p < 0.05). Conclusion: CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases.

AB - Aim: To determine the frequency and topographic distribution of cerebral microbleeds (CMBs) in dementia with Lewy bodies (DLB) in comparison to CMBs in Alzheimer disease dementia (AD). Methods: Consecutive probable DLB (n = 23) patients who underwent 3-T T2* weighted gradient-recalled-echo MRI, and age and gender matched probable Alzheimer's disease patients (n = 46) were compared for the frequency and location of CMBs. Results: The frequency of one or more CMBs was similar among patients with DLB (30%) and AD (24%). Highest densities of CMBs were found in the occipital lobes of patients with both DLB and AD. Patients with AD had greater densities of CMBs in the parietal, temporal lobes and infratentorial regions compared to DLB (p < 0.05). Conclusion: CMBs are as common in patients with DLB as in patients with AD, with highest densities observed in the occipital lobes, suggesting common pathophysiologic mechanisms underlying CMBs in both diseases.

KW - Alzheimer disease

KW - Cerebral amyloid angiopathy

KW - Cerebral microbleeds

KW - Dementia with Lewy bodies

KW - T2 weighted gradient-recalled-echo MRI

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Frequency and topography of cerebral microbleeds in dementia with Lewy bodies compared to Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

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