TY - JOUR
T1 - Frequency and distribution of Alzheimer's disease in Europe
T2 - A collaborative study of 1980–1990 prevalence findings
AU - Rocca, Walter A.
AU - Hofman, Albert
AU - Brayne, Carol
AU - Breteler, Monique M.B.
AU - Clarke, Michael
AU - Copeland, John R.M.
AU - Dartigues, Jean‐Francois ‐F
AU - Engedal, Knut
AU - Hagnell, Olle
AU - Heeren, Thea J.
AU - Jonker, Cees
AU - Lindesay, James
AU - Lobo, Antonio
AU - Mann, Anthony H.
AU - Mölsä, Pekka K.
AU - Morgan, Kevin
AU - O'Connor, Daniel W.
AU - Droux, Arnaldo da Silva
AU - Sulkava, Raimo
AU - Kay, David W.K.
AU - Amaducci, Luigi
PY - 1991/9
Y1 - 1991/9
N2 - We reanalyzed and compared current prevalence estimates of Alzheimer's disease in Europe. Studies characterized as follows qualified for comparison: dementia defined by the Diagnostic and Statistical Manual for Mental Disorders, 3rd edition, or equivalent criteria; Alzheimer's disease diagnosed by the National Institute of Neurological and Communicative Disorders and Stroke‐Alzheimer's Disease and Related Disorders Association or equivalent criteria; case‐finding through direct individual examination; appropriate sample size; and inclusion of institutionalized persons. Of the 23 European surveys of dementia considered, six fulfilled the inclusion criteria. When age and sex were considered, there were no major geographic differences in the prevalence of Alzheimer's disease across Europe. Overall European prevalence (per 100 population) for the age groups 30 to 59, 60 to 69, 70 to 79, and 80 to 89 years was, respectively, 0.02, 0.3, 3.2, and 10.8. Prevalence increased exponentially with advancing age and, in some populations, was consistently higher in women. Prevalence remained stable over 15 years in one study.
AB - We reanalyzed and compared current prevalence estimates of Alzheimer's disease in Europe. Studies characterized as follows qualified for comparison: dementia defined by the Diagnostic and Statistical Manual for Mental Disorders, 3rd edition, or equivalent criteria; Alzheimer's disease diagnosed by the National Institute of Neurological and Communicative Disorders and Stroke‐Alzheimer's Disease and Related Disorders Association or equivalent criteria; case‐finding through direct individual examination; appropriate sample size; and inclusion of institutionalized persons. Of the 23 European surveys of dementia considered, six fulfilled the inclusion criteria. When age and sex were considered, there were no major geographic differences in the prevalence of Alzheimer's disease across Europe. Overall European prevalence (per 100 population) for the age groups 30 to 59, 60 to 69, 70 to 79, and 80 to 89 years was, respectively, 0.02, 0.3, 3.2, and 10.8. Prevalence increased exponentially with advancing age and, in some populations, was consistently higher in women. Prevalence remained stable over 15 years in one study.
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U2 - 10.1002/ana.410300310
DO - 10.1002/ana.410300310
M3 - Article
C2 - 1952826
AN - SCOPUS:0025989415
SN - 0364-5134
VL - 30
SP - 381
EP - 390
JO - Annals of neurology
JF - Annals of neurology
IS - 3
ER -