Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies

Elia Sechi, Karl N. Krecke, Sean J. Pittock, Divyanshu Dubey, A. Sebastian Lopez-Chiriboga, Amy Kunchok, Brian G. Weinshenker, Nicholas L. Zalewski, Eoin P. Flanagan

Research output: Contribution to journalArticle


Background: Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty. Objective and Methods: We retrospectively investigated the frequency of negative spinal cord MRI (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000–2019). Results: The initial spinal cord MRI was negative in 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5–8)); myelitis symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory level, Lhermitte’s phenomenon). Myelitis lesions became overt at follow-up MRI in three patients. Conclusions: A negative spinal cord MRI should not dissuade from MOG-IgG testing in patients with acute/subacute myelitis.

Original languageEnglish (US)
JournalMultiple Sclerosis Journal
StateAccepted/In press - Jan 1 2020



  • acute transverse myelitis
  • Demyelination
  • MRI
  • myelin oligodendrocyte glycoprotein
  • neuromyelitis optica
  • T2 lesions

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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