TY - JOUR
T1 - Frequency and characteristics of MRI-negative myelitis associated with MOG autoantibodies
AU - Sechi, Elia
AU - Krecke, Karl N.
AU - Pittock, Sean J.
AU - Dubey, Divyanshu
AU - Lopez-Chiriboga, A. Sebastian
AU - Kunchok, Amy
AU - Weinshenker, Brian G.
AU - Zalewski, Nicholas L.
AU - Flanagan, Eoin P.
N1 - Publisher Copyright:
© The Author(s), 2020.
PY - 2021/2
Y1 - 2021/2
N2 - Background: Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty. Objective and Methods: We retrospectively investigated the frequency of negative spinal cord MRI (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000–2019). Results: The initial spinal cord MRI was negative in 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5–8)); myelitis symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory level, Lhermitte’s phenomenon). Myelitis lesions became overt at follow-up MRI in three patients. Conclusions: A negative spinal cord MRI should not dissuade from MOG-IgG testing in patients with acute/subacute myelitis.
AB - Background: Myelitis accompanied by a negative spinal cord MRI may lead to diagnostic uncertainty. Objective and Methods: We retrospectively investigated the frequency of negative spinal cord MRI (performed <6 weeks from onset) in Mayo Clinic patients with myelin oligodendrocyte glycoprotein (MOG)-IgG-associated myelitis (2000–2019). Results: The initial spinal cord MRI was negative in 7/73 (10%) patients, despite severe acute disability (median EDSS, 7 (range, 4.5–8)); myelitis symptoms/signs were frequent (paraparesis, neurogenic bladder, sensory level, Lhermitte’s phenomenon). Myelitis lesions became overt at follow-up MRI in three patients. Conclusions: A negative spinal cord MRI should not dissuade from MOG-IgG testing in patients with acute/subacute myelitis.
KW - Demyelination
KW - MRI
KW - T2 lesions
KW - acute transverse myelitis
KW - myelin oligodendrocyte glycoprotein
KW - neuromyelitis optica
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U2 - 10.1177/1352458520907900
DO - 10.1177/1352458520907900
M3 - Article
C2 - 32103708
AN - SCOPUS:85081662227
SN - 1352-4585
VL - 27
SP - 303
EP - 308
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
IS - 2
ER -