Free T4 index and clinical outcome in patients with depression

Osama Abulseoud, Natasha Sane, Anthony Cozzolino, Lindsay Kiriakos, Vishal Mehra, Michael Gitlin, Susan Masseling, Peter Whybrow, Lori L. Altshuler, Jim Mintz, Mark A Frye

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Introduction: Many studies of patients with major depression have reported that a significant decrease in serum free T4 index is associated with specific treatments; what has been unanswered is whether these observations are generalizable. This study evaluated baseline thyroid function and its relationship to rapidity of treatment response as measured by hospital length of stay (HLOS). Methods: Admission thyroid indices and HLOS data were harvested from the medical record of patients hospitalized for depression, both unipolar and bipolar. The relationship between admission thyroid indices and HLOS was evaluated using survival models. Results: Controlling for age and year of discharge, an inverse relationship between FT4 index (FT4I) and HLOS was present in men, but not in women. The mean HLOS stratified by gender and median FT4I was 50% shorter in men with a relatively high FT4I in comparison to the other three groups. Limitations: This is a retrospective study limited by the absence of a structured diagnostic psychiatric interview and prospective controlled antidepressant evaluation. Conclusion: These data would suggest that a relatively elevated FT4 index in depressed men is associated with a faster antidepressant response time. Prospective study is encouraged to further clarify this potential thyroid/gender relationship and whether thyroid supplementation can accelerate the improvement in depression as measured by HLOS.

Original languageEnglish (US)
Pages (from-to)271-277
Number of pages7
JournalJournal of Affective Disorders
Volume100
Issue number1-3
DOIs
StatePublished - Jun 2007
Externally publishedYes

Fingerprint

Length of Stay
Depression
Thyroid Gland
Antidepressive Agents
Depressive Disorder
Bipolar Disorder
Reaction Time
Medical Records
Psychiatry
Retrospective Studies
Prospective Studies
Interviews
Survival
Therapeutics

Keywords

  • Depression
  • Gender
  • Thyroid function
  • Treatment response

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Abulseoud, O., Sane, N., Cozzolino, A., Kiriakos, L., Mehra, V., Gitlin, M., ... Frye, M. A. (2007). Free T4 index and clinical outcome in patients with depression. Journal of Affective Disorders, 100(1-3), 271-277. https://doi.org/10.1016/j.jad.2006.10.012

Free T4 index and clinical outcome in patients with depression. / Abulseoud, Osama; Sane, Natasha; Cozzolino, Anthony; Kiriakos, Lindsay; Mehra, Vishal; Gitlin, Michael; Masseling, Susan; Whybrow, Peter; Altshuler, Lori L.; Mintz, Jim; Frye, Mark A.

In: Journal of Affective Disorders, Vol. 100, No. 1-3, 06.2007, p. 271-277.

Research output: Contribution to journalArticle

Abulseoud, O, Sane, N, Cozzolino, A, Kiriakos, L, Mehra, V, Gitlin, M, Masseling, S, Whybrow, P, Altshuler, LL, Mintz, J & Frye, MA 2007, 'Free T4 index and clinical outcome in patients with depression', Journal of Affective Disorders, vol. 100, no. 1-3, pp. 271-277. https://doi.org/10.1016/j.jad.2006.10.012
Abulseoud O, Sane N, Cozzolino A, Kiriakos L, Mehra V, Gitlin M et al. Free T4 index and clinical outcome in patients with depression. Journal of Affective Disorders. 2007 Jun;100(1-3):271-277. https://doi.org/10.1016/j.jad.2006.10.012
Abulseoud, Osama ; Sane, Natasha ; Cozzolino, Anthony ; Kiriakos, Lindsay ; Mehra, Vishal ; Gitlin, Michael ; Masseling, Susan ; Whybrow, Peter ; Altshuler, Lori L. ; Mintz, Jim ; Frye, Mark A. / Free T4 index and clinical outcome in patients with depression. In: Journal of Affective Disorders. 2007 ; Vol. 100, No. 1-3. pp. 271-277.
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