Frailty in childhood cancer survivors

Kirsten K. Ness, Gregory T. Armstrong, Mondira Kundu, Carmen L. Wilson, Tamara Tchkonia, James L Kirkland

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Young adult childhood cancer survivors are at an increased risk of frailty, a physiologic phenotype typically found among older adults. This phenotype is associated with new-onset chronic health conditions and mortality among both older adults and childhood cancer survivors. Mounting evidence suggests that poor fitness, muscular weakness, and cognitive decline are common among adults treated for childhood malignancies, and that risk factors for these outcomes are not limited to those treated with cranial radiation. Although the pathobiology of this phenotype is not known, early cellular senescence, sterile inflammation, and mitochondrial dysfunction in response to initial cancer or treatment-related insults are hypothesized to play a role. To the authors' knowledge, interventions to prevent or remediate frailty among childhood cancer survivors have not been tested to date. Pharmaceutical, nutraceutical, and lifestyle interventions have demonstrated some promise. Cancer 2015;121:1540-1547.

Original languageEnglish (US)
Pages (from-to)1540-1547
Number of pages8
JournalCancer
Volume121
Issue number10
DOIs
StatePublished - May 1 2015

Fingerprint

Survivors
Neoplasms
Phenotype
Second Primary Neoplasms
Cell Aging
Muscle Weakness
Dietary Supplements
Life Style
Young Adult
Radiation
Inflammation
Mortality
Health
Pharmaceutical Preparations

Keywords

  • aging
  • childhood cancer survivor
  • fitness
  • frailty
  • inflammation
  • mitochondrial dysfunction
  • senescence
  • weakness

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Ness, K. K., Armstrong, G. T., Kundu, M., Wilson, C. L., Tchkonia, T., & Kirkland, J. L. (2015). Frailty in childhood cancer survivors. Cancer, 121(10), 1540-1547. https://doi.org/10.1002/cncr.29211

Frailty in childhood cancer survivors. / Ness, Kirsten K.; Armstrong, Gregory T.; Kundu, Mondira; Wilson, Carmen L.; Tchkonia, Tamara; Kirkland, James L.

In: Cancer, Vol. 121, No. 10, 01.05.2015, p. 1540-1547.

Research output: Contribution to journalArticle

Ness, KK, Armstrong, GT, Kundu, M, Wilson, CL, Tchkonia, T & Kirkland, JL 2015, 'Frailty in childhood cancer survivors', Cancer, vol. 121, no. 10, pp. 1540-1547. https://doi.org/10.1002/cncr.29211
Ness KK, Armstrong GT, Kundu M, Wilson CL, Tchkonia T, Kirkland JL. Frailty in childhood cancer survivors. Cancer. 2015 May 1;121(10):1540-1547. https://doi.org/10.1002/cncr.29211
Ness, Kirsten K. ; Armstrong, Gregory T. ; Kundu, Mondira ; Wilson, Carmen L. ; Tchkonia, Tamara ; Kirkland, James L. / Frailty in childhood cancer survivors. In: Cancer. 2015 ; Vol. 121, No. 10. pp. 1540-1547.
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