Fragile X syndrome: Linkage analysis in black and white populations

C. E. Schwartz, M. C. Phelan, C. Brightharp, I. Pancoast, P. N. Howard-Peebles, S. Thibodeau, W. T. Brown, E. C. Jenkins

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Eleven white families and 10 black families have been studied to detect racial differences in the linkage of DNA markers flanking the fragile X site (FRAXA). The differences in the recombination fractions for F9-FRAXA and DX13-FRAXA were not significant. The pair St14-FRAXA exhibited no difference between the two groups. Although the sample size was small, it would appear that these DNA markers can be used in black persons for prenatal diagnosis and genetic counseling. A larger group of families would be necessary to determine if 4D8 and cX55.7 will be equally useful since these appear to have lower heterozygote frequencies in the black population.

Original languageEnglish (US)
Pages (from-to)531-542
Number of pages12
JournalAmerican journal of medical genetics
Volume30
Issue number1-2
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Schwartz, C. E., Phelan, M. C., Brightharp, C., Pancoast, I., Howard-Peebles, P. N., Thibodeau, S., Brown, W. T., & Jenkins, E. C. (1988). Fragile X syndrome: Linkage analysis in black and white populations. American journal of medical genetics, 30(1-2), 531-542. https://doi.org/10.1002/ajmg.1320300155