Fragile X syndrome: Linkage analysis in black and white populations

C. E. Schwartz, M. C. Phelan, C. Brightharp, I. Pancoast, P. N. Howard-Peebles, Stephen N Thibodeau, W. T. Brown, E. C. Jenkins

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Eleven white families and 10 black families have been studied to detect racial differences in the linkage of DNA markers flanking the fragile X site (FRAXA). The differences in the recombination fractions for F9-FRAXA and DX13-FRAXA were not significant. The pair St14-FRAXA exhibited no difference between the two groups. Although the sample size was small, it would appear that these DNA markers can be used in black persons for prenatal diagnosis and genetic counseling. A larger group of families would be necessary to determine if 4D8 and cX55.7 will be equally useful since these appear to have lower heterozygote frequencies in the black population.

Original languageEnglish (US)
Pages (from-to)531-542
Number of pages12
JournalAmerican Journal of Medical Genetics
Volume30
Issue number1-2
StatePublished - 1988
Externally publishedYes

Fingerprint

Fragile X Syndrome
Genetic Markers
Population
Genetic Counseling
Heterozygote
Prenatal Diagnosis
Sample Size
Genetic Recombination
hydroquinone

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Schwartz, C. E., Phelan, M. C., Brightharp, C., Pancoast, I., Howard-Peebles, P. N., Thibodeau, S. N., ... Jenkins, E. C. (1988). Fragile X syndrome: Linkage analysis in black and white populations. American Journal of Medical Genetics, 30(1-2), 531-542.

Fragile X syndrome : Linkage analysis in black and white populations. / Schwartz, C. E.; Phelan, M. C.; Brightharp, C.; Pancoast, I.; Howard-Peebles, P. N.; Thibodeau, Stephen N; Brown, W. T.; Jenkins, E. C.

In: American Journal of Medical Genetics, Vol. 30, No. 1-2, 1988, p. 531-542.

Research output: Contribution to journalArticle

Schwartz, CE, Phelan, MC, Brightharp, C, Pancoast, I, Howard-Peebles, PN, Thibodeau, SN, Brown, WT & Jenkins, EC 1988, 'Fragile X syndrome: Linkage analysis in black and white populations', American Journal of Medical Genetics, vol. 30, no. 1-2, pp. 531-542.
Schwartz CE, Phelan MC, Brightharp C, Pancoast I, Howard-Peebles PN, Thibodeau SN et al. Fragile X syndrome: Linkage analysis in black and white populations. American Journal of Medical Genetics. 1988;30(1-2):531-542.
Schwartz, C. E. ; Phelan, M. C. ; Brightharp, C. ; Pancoast, I. ; Howard-Peebles, P. N. ; Thibodeau, Stephen N ; Brown, W. T. ; Jenkins, E. C. / Fragile X syndrome : Linkage analysis in black and white populations. In: American Journal of Medical Genetics. 1988 ; Vol. 30, No. 1-2. pp. 531-542.
@article{1c551b9d77ce4f86b5f729b2c26a3a2b,
title = "Fragile X syndrome: Linkage analysis in black and white populations",
abstract = "Eleven white families and 10 black families have been studied to detect racial differences in the linkage of DNA markers flanking the fragile X site (FRAXA). The differences in the recombination fractions for F9-FRAXA and DX13-FRAXA were not significant. The pair St14-FRAXA exhibited no difference between the two groups. Although the sample size was small, it would appear that these DNA markers can be used in black persons for prenatal diagnosis and genetic counseling. A larger group of families would be necessary to determine if 4D8 and cX55.7 will be equally useful since these appear to have lower heterozygote frequencies in the black population.",
author = "Schwartz, {C. E.} and Phelan, {M. C.} and C. Brightharp and I. Pancoast and Howard-Peebles, {P. N.} and Thibodeau, {Stephen N} and Brown, {W. T.} and Jenkins, {E. C.}",
year = "1988",
language = "English (US)",
volume = "30",
pages = "531--542",
journal = "American Journal of Medical Genetics, Part A",
issn = "0148-7299",
publisher = "Wiley-Liss Inc.",
number = "1-2",

}

TY - JOUR

T1 - Fragile X syndrome

T2 - Linkage analysis in black and white populations

AU - Schwartz, C. E.

AU - Phelan, M. C.

AU - Brightharp, C.

AU - Pancoast, I.

AU - Howard-Peebles, P. N.

AU - Thibodeau, Stephen N

AU - Brown, W. T.

AU - Jenkins, E. C.

PY - 1988

Y1 - 1988

N2 - Eleven white families and 10 black families have been studied to detect racial differences in the linkage of DNA markers flanking the fragile X site (FRAXA). The differences in the recombination fractions for F9-FRAXA and DX13-FRAXA were not significant. The pair St14-FRAXA exhibited no difference between the two groups. Although the sample size was small, it would appear that these DNA markers can be used in black persons for prenatal diagnosis and genetic counseling. A larger group of families would be necessary to determine if 4D8 and cX55.7 will be equally useful since these appear to have lower heterozygote frequencies in the black population.

AB - Eleven white families and 10 black families have been studied to detect racial differences in the linkage of DNA markers flanking the fragile X site (FRAXA). The differences in the recombination fractions for F9-FRAXA and DX13-FRAXA were not significant. The pair St14-FRAXA exhibited no difference between the two groups. Although the sample size was small, it would appear that these DNA markers can be used in black persons for prenatal diagnosis and genetic counseling. A larger group of families would be necessary to determine if 4D8 and cX55.7 will be equally useful since these appear to have lower heterozygote frequencies in the black population.

UR - http://www.scopus.com/inward/record.url?scp=0023714290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023714290&partnerID=8YFLogxK

M3 - Article

C2 - 3177470

AN - SCOPUS:0023714290

VL - 30

SP - 531

EP - 542

JO - American Journal of Medical Genetics, Part A

JF - American Journal of Medical Genetics, Part A

SN - 0148-7299

IS - 1-2

ER -