Abstract
Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetylation/deacetylation, ubiquitination and protein-protein interactions. As FOXO factors play a pivotal role in cell fate decision, mounting evidence suggests that FOXO factors function as tumor suppressors in a variety of cancers. FOXOs are actively involved in promoting apoptosis in a mitochondria-independent and -dependent manner by inducing the expression of death receptor ligands, including Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand, and Bcl-2 family members, such as Bim, bNIP3 and Bcl-XL, respectively. An understanding of FOXO proteins and their biology will provide new opportunities for developing more effective therapeutic approaches to treat cancer.
Original language | English (US) |
---|---|
Pages (from-to) | 2312-2319 |
Number of pages | 8 |
Journal | Oncogene |
Volume | 27 |
Issue number | 16 |
DOIs | |
State | Published - Apr 7 2008 |
Keywords
- Apoptosis
- Bcl-2 family members
- Cancer
- Death receptor ligand
- FOXO
- Forkhead
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research