FOXOs, cancer and regulation of apoptosis

Z. Fu, D. J. Tindall

Research output: Contribution to journalReview article

345 Scopus citations

Abstract

Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetylation/deacetylation, ubiquitination and protein-protein interactions. As FOXO factors play a pivotal role in cell fate decision, mounting evidence suggests that FOXO factors function as tumor suppressors in a variety of cancers. FOXOs are actively involved in promoting apoptosis in a mitochondria-independent and -dependent manner by inducing the expression of death receptor ligands, including Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand, and Bcl-2 family members, such as Bim, bNIP3 and Bcl-XL, respectively. An understanding of FOXO proteins and their biology will provide new opportunities for developing more effective therapeutic approaches to treat cancer.

Original languageEnglish (US)
Pages (from-to)2312-2319
Number of pages8
JournalOncogene
Volume27
Issue number16
DOIs
StatePublished - Apr 7 2008

    Fingerprint

Keywords

  • Apoptosis
  • Bcl-2 family members
  • Cancer
  • Death receptor ligand
  • FOXO
  • Forkhead

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Fu, Z., & Tindall, D. J. (2008). FOXOs, cancer and regulation of apoptosis. Oncogene, 27(16), 2312-2319. https://doi.org/10.1038/onc.2008.24