FOXOs, cancer and regulation of apoptosis

Z. Fu, D. J. Tindall

Research output: Contribution to journalArticle

330 Citations (Scopus)

Abstract

Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways and play critical roles in a number of physiological and pathological processes including cancer. The importance of FOXO factors ascribes them under multiple levels of regulation including phosphorylation, acetylation/deacetylation, ubiquitination and protein-protein interactions. As FOXO factors play a pivotal role in cell fate decision, mounting evidence suggests that FOXO factors function as tumor suppressors in a variety of cancers. FOXOs are actively involved in promoting apoptosis in a mitochondria-independent and -dependent manner by inducing the expression of death receptor ligands, including Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand, and Bcl-2 family members, such as Bim, bNIP3 and Bcl-XL, respectively. An understanding of FOXO proteins and their biology will provide new opportunities for developing more effective therapeutic approaches to treat cancer.

Original languageEnglish (US)
Pages (from-to)2312-2319
Number of pages8
JournalOncogene
Volume27
Issue number16
DOIs
StatePublished - Apr 7 2008

Fingerprint

Apoptosis
Forkhead Transcription Factors
Neoplasms
Physiological Phenomena
Ligands
Death Domain Receptors
Critical Pathways
Fas Ligand Protein
Ubiquitination
Pathologic Processes
Acetylation
Mitochondria
Proteins
Tumor Necrosis Factor-alpha
Phosphorylation
Therapeutics

Keywords

  • Apoptosis
  • Bcl-2 family members
  • Cancer
  • Death receptor ligand
  • Forkhead
  • FOXO

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Fu, Z., & Tindall, D. J. (2008). FOXOs, cancer and regulation of apoptosis. Oncogene, 27(16), 2312-2319. https://doi.org/10.1038/onc.2008.24

FOXOs, cancer and regulation of apoptosis. / Fu, Z.; Tindall, D. J.

In: Oncogene, Vol. 27, No. 16, 07.04.2008, p. 2312-2319.

Research output: Contribution to journalArticle

Fu, Z & Tindall, DJ 2008, 'FOXOs, cancer and regulation of apoptosis', Oncogene, vol. 27, no. 16, pp. 2312-2319. https://doi.org/10.1038/onc.2008.24
Fu, Z. ; Tindall, D. J. / FOXOs, cancer and regulation of apoptosis. In: Oncogene. 2008 ; Vol. 27, No. 16. pp. 2312-2319.
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