FOXO1: A potential target for human diseases

Huarui Lu, Haojie Huang

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The forkhead box O (FoxO) transcription factors are known to be involved in many physiological and pathological processes including apoptosis, cell cycle arrest, stress resistance, glucose metabolism, cellular differentiation and development, and tumor suppression. The environmental cues, such as growth factors, nutrients, oxidative stress and irradiation, can either positively or negatively modulate FoxO proteins' activities, thereby ensuring distinctive transcription programs in the cell. The potent activities of FoxOs are tightly controlled by multiple mechanisms, which include posttranslational modification such as phosphorylation, acetylation, methylation and ubiquitination, subcellular localization, and direct protein-protein interaction. Mounting evidence suggests that the human FOXO1 protein, a founding member of the FoxO family is likely involved in carcinogenesis, diabetes and other human diseases. Here we give an overview of most recent findings regarding the regulation and function of FoxO1, its potential role in human diseases and useful animal models for functional studies on FoxO1. Prospective ways in which the discoveries from the basic research of FoxO1 can be utilized for drug targeting and development of novel therapeutics for human diseases are also discussed.

Original languageEnglish (US)
Pages (from-to)1235-1244
Number of pages10
JournalCurrent drug targets
Volume12
Issue number9
DOIs
StatePublished - Aug 1 2011

Keywords

  • Apoptosis
  • Cancer
  • Diabetes
  • Foxo transcription factors
  • Glucose metabolism
  • Muscle atrophy
  • Posttranslational modification
  • The cell cycle

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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