FOXO factors: A matter of life and death

Haojie Huang, Donald J. Tindall

Research output: Contribution to journalReview article

71 Scopus citations

Abstract

Forkhead box O-class (FOXO) transcription factors, including FOXO1, FOXO3a and FOXO4, function as tumor-suppressor proteins by inhibiting cell proliferation, promoting apoptotic cell death and protecting cells from DNA damage and oxidative stress. The potency of these functions is regulated tightly by phosphorylation, acetylation and ubiquitination. Emerging evidence indicates that protein levels of FOXO1 are under dual regulation by Ak-mediated phosphorylation and Skp2-mediated ubiquitination. Given that Akt and Skp2 proteins are highly activated in human cancers due to the loss of phosphatase and tensin homolog (PTEN), deregulation of the FOXO1 protein appears to be a promising target for future drug discovery and cancer therapy.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalFuture Oncology
Volume2
Issue number1
DOIs
StatePublished - Feb 1 2006

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Keywords

  • Akt
  • FOXO proteins
  • FOXO1
  • FOXO3a
  • FOXO4
  • PTEN
  • Phosphorylation
  • Prostate cancer
  • Proteasome degradation
  • Skp2
  • Ubiquitination

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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