FOXO factors: A matter of life and death

Haojie Huang, Donald J. Tindall

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Forkhead box O-class (FOXO) transcription factors, including FOXO1, FOXO3a and FOXO4, function as tumor-suppressor proteins by inhibiting cell proliferation, promoting apoptotic cell death and protecting cells from DNA damage and oxidative stress. The potency of these functions is regulated tightly by phosphorylation, acetylation and ubiquitination. Emerging evidence indicates that protein levels of FOXO1 are under dual regulation by Ak-mediated phosphorylation and Skp2-mediated ubiquitination. Given that Akt and Skp2 proteins are highly activated in human cancers due to the loss of phosphatase and tensin homolog (PTEN), deregulation of the FOXO1 protein appears to be a promising target for future drug discovery and cancer therapy.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalFuture Oncology
Volume2
Issue number1
DOIs
StatePublished - Feb 2006

Fingerprint

Ubiquitination
S-Phase Kinase-Associated Proteins
Phosphorylation
Tumor Suppressor Proteins
Drug Discovery
Acetylation
Phosphoric Monoester Hydrolases
DNA Damage
Neoplasms
Oxidative Stress
Cell Death
Transcription Factors
Cell Proliferation
Forkhead Box Protein O1
Therapeutics
Tensins

Keywords

  • Akt
  • FOXO proteins
  • FOXO1
  • FOXO3a
  • FOXO4
  • Phosphorylation
  • Prostate cancer
  • Proteasome degradation
  • PTEN
  • Skp2
  • Ubiquitination

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

FOXO factors : A matter of life and death. / Huang, Haojie; Tindall, Donald J.

In: Future Oncology, Vol. 2, No. 1, 02.2006, p. 83-89.

Research output: Contribution to journalArticle

Huang, Haojie ; Tindall, Donald J. / FOXO factors : A matter of life and death. In: Future Oncology. 2006 ; Vol. 2, No. 1. pp. 83-89.
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