Four geographically distinct genotypes of JC virus are prevalent in China and Mongolia: Implications for the racial composition of modern China

Jing Guo, Chie Sugimoto, Tadaichi Kitamura, Hideki Ebihara, Atsushi Kato, Zheng Guo, Jing Liu, Shu Ping Zheng, Yue Ling Wang, Yen Qun Na, Makoto Suzuki, Fumiaki Taguchi, Yoshiaki Yogo

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

JC polyomavirus (JCV) is ubiquitous in humans, persisting in renal tissue and excreting progeny in urine. It has been shown that the genotyping of urinary JCV offers a novel means of tracing human migrations. This approach was used to elucidate the racial composition of modern China. JCV isolates in the Old World were previously classified into nine distinct genotypes. One of them (B1) has a wide domain, encompassing part of Europe and the entirety of Asia. By constructing a neighbour-joining phylogenetic tree, all B1 isolates detected so far were classified into four distinct groups (B1-a to -d), each occupying unique domains in the world. According to this revised classification system of JCV DNAs, four genotypes (CY, SC, B1-a and -b) were found to be prevalent in China and Mongolia (Mongolia was studied instead of Inner Mongolia, which is part of China). There was a remarkable variation in the incidence of genotypes among the sites of sample collection. CY was more frequently detected in Northern China, SC was predominant in Southern China and B1-b was detected only in Mongolia. B1-a was spread throughout China. These data were statistically analysed and the observed regional differences in the incidence of genotypes were found to be significant. It is likely that these differences in JCV distribution in China reflect the intermingling of different population groups that constitute modern China.

Original languageEnglish (US)
Pages (from-to)2499-2505
Number of pages7
JournalJournal of General Virology
Volume79
Issue number10
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

Fingerprint

Mongolia
JC Virus
China
Genotype
Human Migration
Incidence
Population Groups
Urine
Kidney

ASJC Scopus subject areas

  • Virology

Cite this

Four geographically distinct genotypes of JC virus are prevalent in China and Mongolia : Implications for the racial composition of modern China. / Guo, Jing; Sugimoto, Chie; Kitamura, Tadaichi; Ebihara, Hideki; Kato, Atsushi; Guo, Zheng; Liu, Jing; Zheng, Shu Ping; Wang, Yue Ling; Na, Yen Qun; Suzuki, Makoto; Taguchi, Fumiaki; Yogo, Yoshiaki.

In: Journal of General Virology, Vol. 79, No. 10, 01.01.1998, p. 2499-2505.

Research output: Contribution to journalArticle

Guo, J, Sugimoto, C, Kitamura, T, Ebihara, H, Kato, A, Guo, Z, Liu, J, Zheng, SP, Wang, YL, Na, YQ, Suzuki, M, Taguchi, F & Yogo, Y 1998, 'Four geographically distinct genotypes of JC virus are prevalent in China and Mongolia: Implications for the racial composition of modern China', Journal of General Virology, vol. 79, no. 10, pp. 2499-2505. https://doi.org/10.1099/0022-1317-79-10-2499
Guo, Jing ; Sugimoto, Chie ; Kitamura, Tadaichi ; Ebihara, Hideki ; Kato, Atsushi ; Guo, Zheng ; Liu, Jing ; Zheng, Shu Ping ; Wang, Yue Ling ; Na, Yen Qun ; Suzuki, Makoto ; Taguchi, Fumiaki ; Yogo, Yoshiaki. / Four geographically distinct genotypes of JC virus are prevalent in China and Mongolia : Implications for the racial composition of modern China. In: Journal of General Virology. 1998 ; Vol. 79, No. 10. pp. 2499-2505.
@article{67c24583e9a84d229a5d4be3268cc37c,
title = "Four geographically distinct genotypes of JC virus are prevalent in China and Mongolia: Implications for the racial composition of modern China",
abstract = "JC polyomavirus (JCV) is ubiquitous in humans, persisting in renal tissue and excreting progeny in urine. It has been shown that the genotyping of urinary JCV offers a novel means of tracing human migrations. This approach was used to elucidate the racial composition of modern China. JCV isolates in the Old World were previously classified into nine distinct genotypes. One of them (B1) has a wide domain, encompassing part of Europe and the entirety of Asia. By constructing a neighbour-joining phylogenetic tree, all B1 isolates detected so far were classified into four distinct groups (B1-a to -d), each occupying unique domains in the world. According to this revised classification system of JCV DNAs, four genotypes (CY, SC, B1-a and -b) were found to be prevalent in China and Mongolia (Mongolia was studied instead of Inner Mongolia, which is part of China). There was a remarkable variation in the incidence of genotypes among the sites of sample collection. CY was more frequently detected in Northern China, SC was predominant in Southern China and B1-b was detected only in Mongolia. B1-a was spread throughout China. These data were statistically analysed and the observed regional differences in the incidence of genotypes were found to be significant. It is likely that these differences in JCV distribution in China reflect the intermingling of different population groups that constitute modern China.",
author = "Jing Guo and Chie Sugimoto and Tadaichi Kitamura and Hideki Ebihara and Atsushi Kato and Zheng Guo and Jing Liu and Zheng, {Shu Ping} and Wang, {Yue Ling} and Na, {Yen Qun} and Makoto Suzuki and Fumiaki Taguchi and Yoshiaki Yogo",
year = "1998",
month = "1",
day = "1",
doi = "10.1099/0022-1317-79-10-2499",
language = "English (US)",
volume = "79",
pages = "2499--2505",
journal = "Journal of General Virology",
issn = "0022-1317",
publisher = "Society for General Microbiology",
number = "10",

}

TY - JOUR

T1 - Four geographically distinct genotypes of JC virus are prevalent in China and Mongolia

T2 - Implications for the racial composition of modern China

AU - Guo, Jing

AU - Sugimoto, Chie

AU - Kitamura, Tadaichi

AU - Ebihara, Hideki

AU - Kato, Atsushi

AU - Guo, Zheng

AU - Liu, Jing

AU - Zheng, Shu Ping

AU - Wang, Yue Ling

AU - Na, Yen Qun

AU - Suzuki, Makoto

AU - Taguchi, Fumiaki

AU - Yogo, Yoshiaki

PY - 1998/1/1

Y1 - 1998/1/1

N2 - JC polyomavirus (JCV) is ubiquitous in humans, persisting in renal tissue and excreting progeny in urine. It has been shown that the genotyping of urinary JCV offers a novel means of tracing human migrations. This approach was used to elucidate the racial composition of modern China. JCV isolates in the Old World were previously classified into nine distinct genotypes. One of them (B1) has a wide domain, encompassing part of Europe and the entirety of Asia. By constructing a neighbour-joining phylogenetic tree, all B1 isolates detected so far were classified into four distinct groups (B1-a to -d), each occupying unique domains in the world. According to this revised classification system of JCV DNAs, four genotypes (CY, SC, B1-a and -b) were found to be prevalent in China and Mongolia (Mongolia was studied instead of Inner Mongolia, which is part of China). There was a remarkable variation in the incidence of genotypes among the sites of sample collection. CY was more frequently detected in Northern China, SC was predominant in Southern China and B1-b was detected only in Mongolia. B1-a was spread throughout China. These data were statistically analysed and the observed regional differences in the incidence of genotypes were found to be significant. It is likely that these differences in JCV distribution in China reflect the intermingling of different population groups that constitute modern China.

AB - JC polyomavirus (JCV) is ubiquitous in humans, persisting in renal tissue and excreting progeny in urine. It has been shown that the genotyping of urinary JCV offers a novel means of tracing human migrations. This approach was used to elucidate the racial composition of modern China. JCV isolates in the Old World were previously classified into nine distinct genotypes. One of them (B1) has a wide domain, encompassing part of Europe and the entirety of Asia. By constructing a neighbour-joining phylogenetic tree, all B1 isolates detected so far were classified into four distinct groups (B1-a to -d), each occupying unique domains in the world. According to this revised classification system of JCV DNAs, four genotypes (CY, SC, B1-a and -b) were found to be prevalent in China and Mongolia (Mongolia was studied instead of Inner Mongolia, which is part of China). There was a remarkable variation in the incidence of genotypes among the sites of sample collection. CY was more frequently detected in Northern China, SC was predominant in Southern China and B1-b was detected only in Mongolia. B1-a was spread throughout China. These data were statistically analysed and the observed regional differences in the incidence of genotypes were found to be significant. It is likely that these differences in JCV distribution in China reflect the intermingling of different population groups that constitute modern China.

UR - http://www.scopus.com/inward/record.url?scp=0031659633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031659633&partnerID=8YFLogxK

U2 - 10.1099/0022-1317-79-10-2499

DO - 10.1099/0022-1317-79-10-2499

M3 - Article

C2 - 9780057

AN - SCOPUS:0031659633

VL - 79

SP - 2499

EP - 2505

JO - Journal of General Virology

JF - Journal of General Virology

SN - 0022-1317

IS - 10

ER -