Forkhead box A2 transcription factor is expressed in all types of neuroendocrine lung tumors

Andras Khoor, Mildred T. Stahlman, Jean M. Johnson, Sandra J. Olson, Jeffrey A. Whitsett

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Forkhead box A2 (Foxa2) is a winged helix nuclear transcription protein that regulates the expression of genes that are critical to lung morphogenesis, differentiation, and function, including thyroid transcription factor-1, surfactant proteins, and Clara cell secretory protein. We examined the immunoreactivity of Foxa2 in paraffin sections of 75 lung tumors: 17 typical carcinoids, 2 atypical carcinoids, 4 large cell neuroendocrine (NE) carcinomas, 23 small cell carcinomas, 19 adenocarcinomas, 7 squamous cell carcinomas, and 3 (non-NE) large cell carcinomas, using a polyclonal rabbit Foxa2 antibody and a biotin-streptavidin detection system. In the adjacent lung, Foxa2 was detected in normal and hyperplastic type II cells. Foxa2 immunoreactivity was detected in 13 typical carcinoids (76%), 2 atypical carcinoids (100%), 2 large cell NE carcinomas (50%), 11 small cell carcinomas (48%), and 1 adenocarcinoma (5%). Squamous cell carcinomas and (non-NE) large cell carcinomas uniformly lacked Foxa2 staining. Expression of Foxa2 in the entire spectrum of NE lung tumors is another indication of differentiation shared by typical carcinoid, atypical carcinoid, large cell NE carcinoma, and small cell carcinoma.

Original languageEnglish (US)
Pages (from-to)560-564
Number of pages5
JournalHuman Pathology
Volume35
Issue number5
DOIs
StatePublished - May 2004

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Forkhead Transcription Factors
Neuroendocrine Tumors
varespladib methyl
Carcinoid Tumor
Large Cell Carcinoma
Lung
Neuroendocrine Carcinoma
Small Cell Carcinoma
Squamous Cell Carcinoma
Adenocarcinoma
Uteroglobin
Streptavidin
Biotin
Nuclear Proteins
Morphogenesis
Surface-Active Agents
Paraffin
Staining and Labeling
Rabbits
Gene Expression

Keywords

  • Carcinoma
  • Immunoreactivity
  • Lung
  • Tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Forkhead box A2 transcription factor is expressed in all types of neuroendocrine lung tumors. / Khoor, Andras; Stahlman, Mildred T.; Johnson, Jean M.; Olson, Sandra J.; Whitsett, Jeffrey A.

In: Human Pathology, Vol. 35, No. 5, 05.2004, p. 560-564.

Research output: Contribution to journalArticle

Khoor, Andras ; Stahlman, Mildred T. ; Johnson, Jean M. ; Olson, Sandra J. ; Whitsett, Jeffrey A. / Forkhead box A2 transcription factor is expressed in all types of neuroendocrine lung tumors. In: Human Pathology. 2004 ; Vol. 35, No. 5. pp. 560-564.
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