Follicular lymphoma presenting with hypercalcaemia: An unusual mechanism of hypercalcaemia

P. Martens, B. Addissie, Rajiv Kumar

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Hypercalcaemia is a frequent finding in patients with cancer. In up to 30% of malignancies, the disease course is complicated with hypercalcaemia. For hospitalized patients, cancer is the most common cause of hypercalcaemia. In normal physiological circumstances, the ionized calcium is kept in check by the influence of two important hormones, parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (1,25(OH)2D). However, cancer can misbalance the calcium homeostasis by generating certain humoural mediators. Overproduction of parathyroid hormone-related peptide (PTH-rp), intact PTH, 1,25(OH)2D, and cytokines all cause hypercalcaemia. Hypercalcaemia is frequent in certain haematological cancers such as multiple myeloma and aggressive lymphomas. But hypercalcaemia is rare in patients with indolent lymphomas such follicular lymphoma. This case illustrates as a first to our knowledge the involvement of cytokines and chemokines in the pathophysiology of lymphoma-related hypercalcaemia. A pathophysio-logical mechanism is offered based upon the current understanding of cytokines and chemokines related to follicular lymphoma.

Original languageEnglish (US)
Pages (from-to)200-203
Number of pages4
JournalActa Clinica Belgica: International Journal of Clinical and Laboratory Medicine
Volume70
Issue number3
DOIs
StatePublished - Jun 1 2015

Fingerprint

Follicular Lymphoma
Hypercalcemia
Lymphoma
Neoplasms
Cytokines
Parathyroid Hormone
Chemokines
Calcium
Parathyroid Hormone-Related Protein
Multiple Myeloma
Homeostasis
Hormones

Keywords

  • Hypercalcaemia
  • Indolent lymphoma
  • Pathophysiology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Follicular lymphoma presenting with hypercalcaemia : An unusual mechanism of hypercalcaemia. / Martens, P.; Addissie, B.; Kumar, Rajiv.

In: Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine, Vol. 70, No. 3, 01.06.2015, p. 200-203.

Research output: Contribution to journalArticle

@article{7d6f354b11484057a4b74709fd1ef5c6,
title = "Follicular lymphoma presenting with hypercalcaemia: An unusual mechanism of hypercalcaemia",
abstract = "Hypercalcaemia is a frequent finding in patients with cancer. In up to 30{\%} of malignancies, the disease course is complicated with hypercalcaemia. For hospitalized patients, cancer is the most common cause of hypercalcaemia. In normal physiological circumstances, the ionized calcium is kept in check by the influence of two important hormones, parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (1,25(OH)2D). However, cancer can misbalance the calcium homeostasis by generating certain humoural mediators. Overproduction of parathyroid hormone-related peptide (PTH-rp), intact PTH, 1,25(OH)2D, and cytokines all cause hypercalcaemia. Hypercalcaemia is frequent in certain haematological cancers such as multiple myeloma and aggressive lymphomas. But hypercalcaemia is rare in patients with indolent lymphomas such follicular lymphoma. This case illustrates as a first to our knowledge the involvement of cytokines and chemokines in the pathophysiology of lymphoma-related hypercalcaemia. A pathophysio-logical mechanism is offered based upon the current understanding of cytokines and chemokines related to follicular lymphoma.",
keywords = "Hypercalcaemia, Indolent lymphoma, Pathophysiology",
author = "P. Martens and B. Addissie and Rajiv Kumar",
year = "2015",
month = "6",
day = "1",
doi = "10.1179/2295333714Y.0000000106",
language = "English (US)",
volume = "70",
pages = "200--203",
journal = "Acta Clinica Belgica",
issn = "1784-3286",
publisher = "Acta Clinica Belgica",
number = "3",

}

TY - JOUR

T1 - Follicular lymphoma presenting with hypercalcaemia

T2 - An unusual mechanism of hypercalcaemia

AU - Martens, P.

AU - Addissie, B.

AU - Kumar, Rajiv

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Hypercalcaemia is a frequent finding in patients with cancer. In up to 30% of malignancies, the disease course is complicated with hypercalcaemia. For hospitalized patients, cancer is the most common cause of hypercalcaemia. In normal physiological circumstances, the ionized calcium is kept in check by the influence of two important hormones, parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (1,25(OH)2D). However, cancer can misbalance the calcium homeostasis by generating certain humoural mediators. Overproduction of parathyroid hormone-related peptide (PTH-rp), intact PTH, 1,25(OH)2D, and cytokines all cause hypercalcaemia. Hypercalcaemia is frequent in certain haematological cancers such as multiple myeloma and aggressive lymphomas. But hypercalcaemia is rare in patients with indolent lymphomas such follicular lymphoma. This case illustrates as a first to our knowledge the involvement of cytokines and chemokines in the pathophysiology of lymphoma-related hypercalcaemia. A pathophysio-logical mechanism is offered based upon the current understanding of cytokines and chemokines related to follicular lymphoma.

AB - Hypercalcaemia is a frequent finding in patients with cancer. In up to 30% of malignancies, the disease course is complicated with hypercalcaemia. For hospitalized patients, cancer is the most common cause of hypercalcaemia. In normal physiological circumstances, the ionized calcium is kept in check by the influence of two important hormones, parathyroid hormone (PTH) and 1,25-dihydroxyvitamin D (1,25(OH)2D). However, cancer can misbalance the calcium homeostasis by generating certain humoural mediators. Overproduction of parathyroid hormone-related peptide (PTH-rp), intact PTH, 1,25(OH)2D, and cytokines all cause hypercalcaemia. Hypercalcaemia is frequent in certain haematological cancers such as multiple myeloma and aggressive lymphomas. But hypercalcaemia is rare in patients with indolent lymphomas such follicular lymphoma. This case illustrates as a first to our knowledge the involvement of cytokines and chemokines in the pathophysiology of lymphoma-related hypercalcaemia. A pathophysio-logical mechanism is offered based upon the current understanding of cytokines and chemokines related to follicular lymphoma.

KW - Hypercalcaemia

KW - Indolent lymphoma

KW - Pathophysiology

UR - http://www.scopus.com/inward/record.url?scp=84942739944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942739944&partnerID=8YFLogxK

U2 - 10.1179/2295333714Y.0000000106

DO - 10.1179/2295333714Y.0000000106

M3 - Article

C2 - 25475431

AN - SCOPUS:84942739944

VL - 70

SP - 200

EP - 203

JO - Acta Clinica Belgica

JF - Acta Clinica Belgica

SN - 1784-3286

IS - 3

ER -