TY - JOUR
T1 - Focused ultrasound treatment of uterine fibroid tumors
T2 - Safety and feasibility of a noninvasive thermoablative technique
AU - Stewart, Elizabeth A.
AU - Gedroyc, Wladyslaw M.W.
AU - Tempany, Clare M.C.
AU - Quade, Bradley J.
AU - Inbar, Yael
AU - Ehrenstein, Tilman
AU - Shushan, Asher
AU - Hindley, Jonathan T.
AU - Goldin, Robert D.
AU - David, Matthias
AU - Sklair, Miri
AU - Rabinovici, Jaron
N1 - Funding Information:
Supported by Insightec, Ltd (Haifa, Israel) and by National Institutes of Health grants No. P01 CA 67165-06 and CA 46627 (Bethesda, Md).
PY - 2003/7/1
Y1 - 2003/7/1
N2 - OBJECTIVE: The purpose of this study was to determine the safety and efficacy of focused ultrasound surgery with magnetic resonance imaging guidance for the noninvasive treatment of uterine leiomyomas. STUDY DESIGN: Fifty-five women with clinically significant uterine leiomyomas were treated. Pain and complications were assessed prospectively, and posttreatment magnetic resonance imaging was used to measure the treatment effects. Patients in three of the five centers underwent planned hysterectomy after treatment, which provided pathologic correlation of treatment. RESULTS: Seventy-six percent of the enrolled patients completed the full treatment session. All treatments were conducted in an outpatient setting with minimal discomfort for subjects and no major complications. Pathologic examination of the uterus confirmed that magnetic resonance imaging guidance provides the safe and accurate delivery of effective levels of thermal energy with a 3-fold increase in volume of histologically documented necrosis, compared with treatment volume (6.6 ± 0.8 vs 18.4 ± 3.9 mL, P < .005). CONCLUSION: Magnetic resonance imaging-guided focused ultrasound surgery appears to be a well-tolerated treatment for uterine leiomyomas.
AB - OBJECTIVE: The purpose of this study was to determine the safety and efficacy of focused ultrasound surgery with magnetic resonance imaging guidance for the noninvasive treatment of uterine leiomyomas. STUDY DESIGN: Fifty-five women with clinically significant uterine leiomyomas were treated. Pain and complications were assessed prospectively, and posttreatment magnetic resonance imaging was used to measure the treatment effects. Patients in three of the five centers underwent planned hysterectomy after treatment, which provided pathologic correlation of treatment. RESULTS: Seventy-six percent of the enrolled patients completed the full treatment session. All treatments were conducted in an outpatient setting with minimal discomfort for subjects and no major complications. Pathologic examination of the uterus confirmed that magnetic resonance imaging guidance provides the safe and accurate delivery of effective levels of thermal energy with a 3-fold increase in volume of histologically documented necrosis, compared with treatment volume (6.6 ± 0.8 vs 18.4 ± 3.9 mL, P < .005). CONCLUSION: Magnetic resonance imaging-guided focused ultrasound surgery appears to be a well-tolerated treatment for uterine leiomyomas.
KW - Magnetic resonance imaging
KW - Uterine leiomyomas
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U2 - 10.1067/mob.2003.345
DO - 10.1067/mob.2003.345
M3 - Article
C2 - 12861137
AN - SCOPUS:0038675046
SN - 0002-9378
VL - 189
SP - 48
EP - 54
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
IS - 1
ER -